Results 81 to 90 of about 17,019 (205)

Structure of the lectin mannose 6-phosphate receptor homology (MRH) domain of glucosidase II an enzyme that regulates glycoprotein folding quality control in the endoplasmic reticulum [PDF]

, 2013
Here we report for the first time the three-dimensional structure of a mannose 6-phosphate receptor homology (MRH) domain present in a protein with enzymatic activity, glucosidase II (GII).
Alculumbre, Solana G., D'alessio, Cecilia, Dahms, Nancy M., Olson, Linda J., Orsi, Ramiro, Parodi, Armando Jose A., Peterson, Francis C., Stigliano, Ivan Daniel   +7 more
core   +1 more source

The C proteins of human parainfluenza virus type 1 block IFN signaling by binding and retaining Stat1 in perinuclear aggregates at the late endosome. [PDF]

PLoS ONE, 2012
Interferons (IFNs) play a crucial role in the antiviral immune response. Whereas the C proteins of wild-type human parainfluenza virus type 1 (WT HPIV1) inhibit both IFN-β induction and signaling, a HPIV1 mutant encoding a single amino acid substitution (
Henrick Schomacker, Rebecca M Hebner, Jim Boonyaratanakornkit, Sonja Surman, Emerito Amaro-Carambot, Peter L Collins, Alexander C Schmidt   +6 more
doaj   +1 more source

Cloning and expression of the cDNA of chicken cation-independent mannose-6-phosphate receptor. [PDF]

Proceedings of the National Academy of Sciences, 1995
We cloned and sequenced the 8767-bp full-length cDNA for the chicken cation-independent mannose-6-phosphate receptor (CI-MPR), of interest because, unlike its mammalian homologs, it does not bind insulin-like growth factor II (IGF-II). The cDNA encodes a protein of 2470 aa that includes a putative signal sequence, an extracytoplasmic domain consisting ...
M, Zhou, Z, Ma, W S, Sly
openaire   +2 more sources

Lysosomal and vacuolar sorting: not so different after all! [PDF]

, 2016
Soluble hydrolases represent the main proteins of lysosomes and vacuoles and are essential to sustain the lytic properties of these organelles typical for the eukaryotic organisms.
Appelmans, Bandyopadhyay, Bergeland, Blanz, Bohnsack, Bowers, Boya, Braulke, Carine de Marcos Lousa, Coutinho, Dahms, de Duve, De Marcos Lousa, Eskelinen, Ferguson, Gary Bobo, Gershlick, Gershlick, Ghosh, Gonzalez, Hecht, Hermey, Jurgen Denecke, Jørgensen, Klionsky, Klionsky, Klumperman, Kornfeld, Li, Limkul, Luo, Marchis, Martinière, Marty, McCormick, Miao, Mindell, Morgan, Nakamura, Niemes, Novikoff, Olson, Owens, Pereira, Platt, Preston, Reczek, Rehling, Saftig, Shaaltiel, Steinman, Steinman, Strong, Tong, Valls, van Leeuwenhoek, van Voorst, Wang, Watanabe, Weisman, Weisman, Westphal, Whyte, Zhang, Zhao   +64 more
core   +2 more sources

Differential Sensitivity of Human Hepatocellular Carcinoma Xenografts to an IGF-II Neutralizing Antibody May Involve Activated STAT3

Translational Oncology, 2018
Hepatocellular carcinoma (HCC) is highly refractory to current therapeutics used in the clinic. DX-2647, a recombinant human antibody, potently neutralizes the action of insulin-like growth factor-II (IGF-II), a ligand for three cell-surface receptors ...
Sameer A. Greenall, Jacqueline Donoghue, Terrance G. Johns, Timothy E. Adams   +3 more
doaj   +1 more source

Signaling pathways for transduction of the initial message of the glycocode into cellular responses [PDF]

, 1998
The sugar units of glycan structures store information and establish an alphabet of life. The language of the oligosaccharide coding units is deciphered by receptors such as lectins and the decoded message can be transduced by multiple signaling pathways.
Gabius, Hans-Joachim, Villalobo, A.
core   +2 more sources

The phosphorylation of sorting nexin 5 at serine 226 regulates retrograde transport and macropinocytosis. [PDF]

PLoS ONE, 2018
Sorting nexin 5 (SNX5), a member of sorting nexin family, plays an important role in membrane trafficking, including the retrograde trafficking of the cation independent mannose 6-phosphate receptor (CI-M6PR) and macropinocytosis.
Nao Itai, Tsukasa Shimazu, Takayuki Kimura, Issei Ibe, Ryo Yamashita, Yasushi Kaburagi, Taeko Dohi, Takashi Tonozuka, Toshifumi Takao, Atsushi Nishikawa   +9 more
doaj   +1 more source

Comparative study on incorporation of three recombinant human α-galactosidase A drugs (agalsidases) into cultured fibroblasts and organs/tissues of Fabry mice

Molecular Genetics and Metabolism Reports
Enzyme replacement therapy (ERT) with recombinant human α-galactosidase A (α-Gal A) drugs (agalsidases) has been successfully used for treatment of Fabry disease, and three kinds of agalsidases are now available in Japan.
Takahiro Tsukimura, Tomoko Shiga, Tadayasu Togawa, Hitoshi Sakuraba   +3 more
doaj   +1 more source

Autophagy-associated circular RNA hsa_circ_0007813 modulates human bladder cancer progression via hsa-miR-361-3p/IGF2R regulation

Cell Death and Disease, 2021
Circular RNAs (circRNAs) drive several cellular processes including proliferation, survival, and differentiation. Here, we identified a circRNA hsa_circ_0007813, whose expression was upregulated in bladder cancer.
Zheyu Zhang, Zezhong Mou, Chenyang Xu, Siqi Wu, Xiyu Dai, Xinan Chen, Yuxi Ou, Yiling Chen, Chen Yang, Haowen Jiang   +9 more
doaj   +1 more source

DmCatD, a cathepsin D-like peptidase of the hematophagous insect Dipetalogaster maxima (Hemiptera: Reduviidae): Purification, bioinformatic analyses and the significance of its interaction with lipophorin in the internalization by developing oocytes [PDF]

, 2018
DmCatD, a cathepsin D-like peptidase of the hematophagous insect Dipetalogaster maxima, is synthesized by the fat body and the ovary and functions as yolk protein precursor. Functionally, DmCatD is involved in vitellin proteolysis.
Arrese, Estela L., Canavoso, Lilian Etelvina, Carlini, Célia Regina R S, Defferrari, Marina S., Fruttero, Leonardo Luis, Leyria, Jimena, Ligabue Braun, Rodrigo, Settembrini, Beatriz Patricia, Soulages, José L.   +8 more
core   +1 more source