Results 91 to 100 of about 537,647 (300)

Comparisons of the efficacy of alpha glucosidase inhibitors on type 2 diabetes patients between Asian and Caucasian.

PLoS ONE, 2013
BackgroundTo compare the efficacy of glycemic control and insulin secretion of alpha glucosidase inhibitors (AGI) on type 2 diabetes patients between Asian and Caucasian.Methodology/principal findingsThe MEDLINE®, EMBASE®, CENTRAL were searched and ...
Xiaoling Cai, Xueyao Han, Yingying Luo, Linong Ji   +3 more
doaj   +1 more source

Seeing two faces together: preference formation in humans and rhesus macaques [PDF]

, 2014
Humans, great apes and old world monkeys show selective attention to faces depending on conspecificity, familiarity, and social status supporting the view that primates share similar face processing mechanisms.
C Michel, C Taylor, CD Dahl, CD Dahl, CN Macrae, David Méary, DJ Kelly, E Giorgio Di, I Rentschler, J Park, JW Tanaka, K Fujita, KJ Johnson, KM Gothard, KM Gothard, Kun Guo, L Ge, LA Parr, M Enquist, M Heron-Delaney, MD Leinbach, Olivier Pascalis, PC Quinn, R Engbert, R McFarland, RB Zajonc, RF Bornstein, RL Fantz, S Hirata, TK Leonard, Wu Li, Y Sugita, Zhihan Li   +32 more
core   +3 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Raman spectroscopy and electronic microscopy structural studies of Caucasian and Afro human hair

Heliyon, 2019
Human hair fibre is subjected to various structural modifications due to the application of chemicals such as dyes, shampoos and bleaches and/or physical procedures such as heating, and often more than one procedure is performed on the same hair.
Jordana Dias dos Santos, Howell G.M. Edwards, Luiz Fernando Cappa de Oliveira   +2 more
doaj   +1 more source

Immunohistochemical Expression of Matrix Metalloprotease-2 and Matrix Metalloprotease-9 in the Disks of Patients with Temporomandibular Joint Dysfunction [PDF]

, 2015
Purpose Matrix metalloproteases (MMPs) are tissue-remodeling enzymes that function during the remodeling process, such as in immune-inflammatory diseases.
Almeida, Luis Eduardo, Ambros, Viviane, Azevedo, Marina, Caporal, Karina, Leonardi, Rosy, Noronha, Lucia, Trevilatto, Paula C.   +6 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The Genre of “Memoir of a Map” in Linguistic Geography of the 18th Century

Известия Южного федерального университета: Филологические науки, 2017
The paper is devoted to the rare genre of «memoir of a map» widespread in Great Britain in the 18th century. The authors analyze the little-known George Ellis’s book «Memoir of a Map of the Countries Comprehended Between the Black Sea and the Caspian ...
Denis I. Petrenko, Klara E. Shtain
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Language and Identity in Historical Caucasian German

Cadernos de Linguística
Varieties of German outside the German-speaking area in Europe are often in close contact with surrounding languages and differ from Standard German with respect to various linguistic phenomena. We present a study on a diasporic variety of German spoken
Doris Stolberg, Katharina Dück
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source