Results 91 to 100 of about 3,950,087 (325)

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

Caudal Block Compared to Acetaminophen for Prospective Pain Relief in Pediatric Patients

, 2000
Postoperative pain assessment and management in the pediatric population has long been difficult and inadequate. Caudal blocks have long been shown to be effective and safe for providing analgesia and anesthesia.
Wells, Sue, Koehn, Eric
core   +5 more sources

Ultrasound‐guided quadratus lumborum block compared to caudal ropivacaine/morphine in children undergoing surgery for vesicoureteric reflex

Paediatric anaesthesia, 2019
Ultrasound‐guided quadratus lumborum block is a regional anesthetic technique which can provide perioperative analgesia for all age groups, including pediatric patients undergoing abdominal surgery. We hypothesized that the quadratus lumborum block would
Makoto Sato
semanticscholar   +1 more source

Autotomy, tail regeneration and jumping ability in Cape dwarf geckos (Lygodactylus capensis) (Gekkonidae) [PDF]

, 2012
Many studies have examined the effect of caudal autotomy on speed and behaviour of lizards escaping over horizontal surfaces, but there have been few studies on lizards escaping over vertical surfaces and, in particular, species that jump between ...
Philip W. Bateman, Bateman, P.W., Patricia A. Fleming, Fleming, P.A., Bateman, Philip W., Fleming, Patricia A.   +5 more
core  

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source

Assessment of surgeon performed caudal block for anorectal surgery.

Asian Journal of Surgery, 2019
BACKGROUND The surgical anorectal diseases are common and distressful pathologies and their management mostly needs surgical intervention. Caudal anesthesia is effective in doing surgical procedures whenever the surgical area is mainly innervated by the ...
Muhammed Hassen Jaffar Al-Sa'adi
semanticscholar   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Postoperative complications of hypospadias repair in patients receiving caudal block vs. non-caudal anesthesia: A meta-analysis.

Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2018
INTRODUCTION We performed a meta-analysis of the current literature to assess the association of caudal block and postoperative complication rates following hypospadias repair. METHODS A Systematic literature search was conducted on October 2017.
Patrick P. Tanseco, Harkanwal Randhawa, M. Chua, U. Blankstein, J. Kim, M. McGrath, A. Lorenzo, L. Braga   +7 more
semanticscholar   +1 more source

Pudendal Versus Caudal Block in Children Undergoing Hypospadias Surgery A Randomized Controlled Trial

, 2016
Background and Objectives: Postoperative pain management after hypospadias surgery is often challenging. Caudal block is used for analgesia but has limitations.
Kaya, Guner, Altindas, Fatis, Kendigelen, Pinar, Tutuncu, Ayse Cigdem, Şenol, Yunus Emre   +4 more
core   +1 more source

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source