Results 111 to 120 of about 3,950,087 (325)

Ultrasound-guided rectus sheath block, caudal analgesia, or surgical site infiltration for pediatric umbilical herniorrhaphy: a prospective, double-blinded, randomized comparison of three regional anesthetic techniques

, 2017
Lance M Relland,1,2 Joseph D Tobias,1–3 David Martin,1,2 Giorgio Veneziano,1,2 Ralph J Beltran,1,2 Christopher McKee,1,2 Tarun Bhalla1,2 1Department of Anesthesiology and Pain Medicine, Nationwide Children’s Hospital, 2Department of ...
Tobias JD, Relland LM, Beltran RJ, McKee C, Bhalla T, Martin D, Veneziano G   +6 more
core  

TH/TRs–COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains

Advanced Science, EarlyView.
Using a gyrencephalic congenital hypothyroidism pig model, this study reveals cerebral atrophy and cortical hypogyrification. Single‐cell sequencing identifies astrocytes as major TH‐responsive cells, with the COL11A2‐enriched Astro‐2 state nearly absent.
Ying Zhang, Xiao Wang, Hongyan Ma, Pengcheng Lyu, Shuangjie Tian, Ruojun Zong, Jiani Chen, Gang Ren, Yongjiang Yang, Zichen Yang, Guosong Qin, Naishi Li, Yanfang Wang, Jianwei Jiao, Jianguo Zhao   +14 more
wiley   +1 more source

Effect of Caudal Dexmedetomidine on Emergence Agitation after Infra Umbilical Pediatric Surgeries [PDF]

Zagazig University Medical Journal
Background: The incidence of postoperative agitation could be reduced using intravenous dexmedetomidine. At the same time, on the other side, it could cause a delay in discharge from the hospital and a higher incidence of hypotension. This study aimed to
Khaled Helmy, Ahmed Salama, Moaz Elbahrawy, Salwa El Sherbeny   +3 more
doaj   +1 more source

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source

Evaluation of caudal epidural anesthesia efficacy by measurement of feet skin temperature in children

Zaporožskij Medicinskij Žurnal, 2015
Caudal epidural anesthesia in children is not performed in pure form, but only in combination with superficial general anesthesia. Therefore, a search for reliable evaluation criteria of the caudal epidural block onset in children remains actual. Aim.
M. Yu. Kurochkin
doaj   +1 more source

Acid‐Responsive Nanobot‐Integrated Core‐Shell Microneedles Reprogram the Degenerative Annulus Fibrosus Microenvironment Through Epigenetic Suppression of Ferroptosis

Advanced Science, EarlyView.
An acid‐responsive core‐shell microneedle system normalizes the degenerative annulus fibrosus microenvironment by consuming pathological H+, generating O2, and providing NIR‐amplified redox buffering. Mechanistically, it epigenetically suppresses ferroptosis via DNMT3A‐dependent methylation of the ATF3 promoter, relieving ATF3‐mediated repression of ...
Lu Tan, Yan Zheng, Yue Lan, Zhuo Cheng, Siya Wang, Changqing Li, Yanqiu Wang, Minghan Liu   +7 more
wiley   +1 more source

Comparative Study between Ultrasound Guided Quadratus Lumborum Block versus Caudal Block for Postoperative Analgesia in Lower Abdominal Surgery in Pediatrics [PDF]

Al-Azhar International Medical Journal
Background: There is growing evidence of the utilization of regional anesthesia in pediatric patients scheduled for lower abdominal surgery.Aim: To assess the effectiveness of ultrasound-guided quadratus lumborum block (QLB) with ultrasound-guided caudal
doaj   +1 more source

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source

The effect of adjunct caudal block on postoperative analgesia in robot-assisted laparoscopic radical prostatectomy: A prospective randomized controlled, single blinded pilot study in a tertiary centre

Asian Journal of Urology, 2018
Objective: Caudal block provides satisfactory postoperative pain relief in lower abdominal operations. This pilot study explores its safety and effect on postoperative pain control in patients who underwent robot-assisted laparoscopic radical ...
Kenneth Chen, Allen Sim, Alex Ford Kan
doaj   +1 more source

Comparison of Analgesic Efficacy of Caudal Dexamethasone with Intravenous Dexamethasone as an Adjuvant to Caudal Block in Pediatric Patients Undergoing Urogenital Surgeries

Anesthesia Essays and Researches, 2017
Context: Caudal block is one of the most common regional anesthetic techniques employed in pediatric urogenital surgeries. Adjuvants play an important role to improve postoperative analgesia.
Dhanashree H. Dongare, S. Karhade
semanticscholar   +1 more source