Results 121 to 130 of about 694,836 (334)

Additional file 1 of Genomic correlation, shared loci, and causal relationship between obesity and polycystic ovary syndrome: a large-scale genome-wide cross-trait analysis

, 2022
Qianwen Liu, Zhaozhong Zhu, Peter Kraft, Qiaolin Deng, Elisabet Stener‐Victorin, Xia Jiang   +5 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Age‐Related Genetic Causal Association Between Asthma and Delirium: A Bidirectional Two‐Sample Mendelian Randomization

Brain and Behavior
Introduction Despite observational studies suggesting a link between asthma and delirium, establishing a definitive causal relationship has been challenging. This study aims to investigate the genetic causality between these conditions, with a particular
Xiaopeng Wang, Guangquan Guo, Jinfeng Liu   +2 more
doaj   +1 more source

Additional file 10 of KNIME workflow for retrieving causal drug and protein interactions, building networks, and performing topological enrichment analysis demonstrated by a DILI case study

, 2022
Barbara Füzi, Rahuman S. Malik‐Sheriff, Emma J. Manners, Henning Hermjakob, Gerhard F. Ecker   +4 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Statistical causality analysis

Discrete and Continuous Models and Applied Computational Science
The problem of identifying deterministic cause-and-effect relationships, initially hidden in accumulated empirical data, is discussed. Statistical methods were used to identify such relationships. A simple mathematical model of cause-and-effect relationships is proposed, in the framework of which several models of causal dependencies in data are ...
Alexander A. Grusho, Nikolai A. Grusho, Michael I. Zabezhailo, Konstantin E. Samouylov, Elena E. Timonina   +4 more
openaire   +2 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Climbing the STAIRs: Assessing students’ social scientific reasoning skills

Journal of Social Science Education
Highlights: - Assessing complex skills in secondary school teaching practice is considered challenging - We developed items (STAIRs) to formatively assess students’ social scientific reasoning - STAIRs were validated by experts, teachers, think-aloud ...
Thomas Klijnstra, Geerte Savenije, Chiel Huijskes, Carla van Boxtel   +3 more
doaj  

DINER: Debiasing Aspect-based Sentiment Analysis with Multi-variable Causal Inference [PDF]

Jialong Wu, Linhai Zhang, Deyu Zhou, Guoqiang Xu   +3 more
openalex   +1 more source