Results 111 to 120 of about 9,491,507 (312)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Unraveling the causal link: fatty acids and inflammatory bowel disease

Frontiers in Immunology
BackgroundPrevious observational studies have revealed the strong relationship between fatty acids (FA) and inflammatory bowel disease (IBD). Nonetheless, due to the inherent limitations of retrospective research, the causality between the two has not ...
Yi Zhou, Zhenhua Zhou
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Exploring the associations of plasma proteins with frailty based on Mendelian randomization

BMC Immunology
Background Frailty is an emerging global burden of disease, characterized as an age-related clinical syndrome. Recent studies have suggested a potential link of circulating protein levels with the onset of frailty.
Shuhui Chen, Hao Lin, Bin Liu, Hejing Pan, Yaling Xu, Yingying Mao, Lin Huang   +6 more
doaj   +1 more source

Mendelian randomization analysis of the causal association between metabolite and skin cancer

Dermatology Reports
Skin cancer (SC) is a significant public health issue, with increasing incidence rates globally. Although environmental factors such as ultraviolet (UV) exposure are recognized risk factors, the impact of metabolites on SC development has not been ...
Duanyu Wang, Minghao Tan, Nora Iv, Rattanaricky Ung, Gechhorng Lim, Vahid Say, Sokheng Phal, Pengkhun Nov   +7 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Onchocerciasis associated epilepsy—A question of causality [PDF]

International Journal of Infectious Diseases, 2019
Cantey, Paul T., Sejvar, James
openaire   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Omeprazole and risk of osteoarthritis: insights from a mendelian randomization study in the UK Biobank

Journal of Translational Medicine
Background A former cohort study has raised concern regarding the unanticipated hazard of omeprazole in expediting osteoarthritis (OA) advancement. The precise nature of their causal evidence, however, remains undetermined. The present research endeavors
Siyang Cao, Yihao Wei, Yaohang Yue, Guoqing Li, Hongli Wang, Jianjing Lin, Qichang Wang, Peng Liu, Fei Yu, Ao Xiong, Hui Zeng   +10 more
doaj   +1 more source