Results 131 to 140 of about 9,491,507 (312)

IFN-γ, SCF, MIP1b and IL-16 Were Associated with Risk of Diabetic Nephropathy: A Mendelian Randomization Study

Diabetes, Metabolic Syndrome and Obesity
Li An,1,2,* Xiaomei Ren,1,* Ye Pan,2 Wei Gao,1 Liqun Ren,1 Jing Wang,3 Yao Wang2 1Department of Geriatrics, ZhongDa Hospital, Southeast University School of Medicine, Nanjing, 210009, People’s Republic of China; 2Department of Endocrine, ZhongDa ...
An L, Ren X, Pan Y, Gao W, Ren L, Wang J, Wang Y   +6 more
doaj  

Hemorrhoids and cardiovascular disease: A bidirectional Mendelian randomization study

Open Medicine
Emerging evidence suggests that hemorrhoids are associated with cardiovascular disease (CVD). However, the causal associations between hemorrhoids and CVD remain elusive.
Ge Xin, Tang Weixin, Ni Jingmin
doaj   +1 more source

Foreign direct investment and corruption in developing economies: Evidence from linear and non-linear panel Granger causality tests [PDF]

This paper determines the causal link between FDI and corruption in 42 developing countries using linear and non linear panel Granger causal methods over the period 1998 to 2009. The findings show that the outcome of the causal association depends on the
Roland Craigwell, Allan Wright
core  

Inferring Causal Complexity [PDF]

, 2006
In "The Comparative Method" Ragin (1987) has outlined a procedure of Boolean causal reasoning operating on pure coincidence data that has meanwhile become widely known as QCA (Qualitative Comparative Analysis) among social scientists.
Baumgartner, Michael
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Additional file 4: Figure S3. of A powerful score-based test statistic for detecting gene-gene co-association

, 2016
The power of the seven methods under different co-association levels with no main effect (β 1 = 0, β 2 = 0). Note: figure a for Type I co-association with different interaction effects; figure b for Type II co-association with different causal SNP pairs;
Zhongshang Yuan (180937), Jiadong Ji (3467288), Xuesen Wu (241094), Jing Xu (1234089), Fuzhong Xue (116249), Yanxun Liu (116240), Hongkai Li (560311), Xiaoshuai Zhang (404718)   +7 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Causal association between atopic dermatitis and Parkinson's disease: A bidirectional Mendelian randomization study

Brain and Behavior
Background Atopic dermatitis is one of the most common skin disorders. Evidence has suggested an association between skin disorders, such as atopic dermatitis, and Parkinson's disease (PD).
Taofeng Zhou, Baohao Wei, Yachun Hu, Xiaoming Zhou, Xiaoying Cai, Xiaolei Shi   +5 more
doaj   +1 more source