Results 91 to 100 of about 16,076,570 (308)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

A National Multicity Analysis of the Causal Effect of Local Pollution, NO2, and PM2.5 on Mortality

Environmental Health Perspectives, 2018
Background: Studies have long associated PM2.5 with daily mortality, but few applied causal-modeling methods, or at low exposures. Short-term exposure to NO2, a marker of local traffic, has also been associated with mortality but is less studied.
J. Schwartz, K. Fong, A. Zanobetti
semanticscholar   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Independent causal effect of migraines on Alzheimer’s disease risk: a multivariate Mendelian randomization study

Frontiers in Neurology
BackgroundThe observational studies investigated the impact of migraine on Alzheimer’s Disease (AD). However, these findings were limited by confounding factors and reverse causation, leading to contradictory results.MethodsWe utilized Univariable ...
Chengfeng Xu, Wen Wu, Yuchao Fan, Shuying Zhu   +3 more
doaj   +1 more source

The Causal Effect of Radical Right Success on Mainstream Parties’ Policy Positions: A Regression Discontinuity Approach

British Journal of Political Science, 2018
This article investigates how the success of radical right parties affects the policy positions of mainstream parties. We do this using a regression discontinuity approach that allows us to causally attribute mainstream parties’ positional changes to ...
Tarik Abou-Chadi, Werner Krause
semanticscholar   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Directed causal effect with PCMCI in hyperscanning EEG time series

Frontiers in Neuroscience
Social activities are likely to cause effects or reactivity in the brains of the people involved in collaborative social situations. This study assesses a new method, Tigramite, for time domain analysis of directed causality between the prefrontal cortex
Lykke Silfwerbrand, Lykke Silfwerbrand, Yasuharu Koike, Pär Nyström, Malin Gingnell, Malin Gingnell   +5 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Causal Bayes Model of Mathematical Competence in Kindergarten [PDF]

Journal of Systemics, Cybernetics and Informatics, 2016
In this paper authors define mathematical competences in the kindergarten. The basic objective was to measure the mathematical competences or mathematical knowledge, skills and abilities in mathematical education. Mathematical competences were grouped in
Božidar Tepeš, Gordana Lešin, Ana Hrkač, Krunoslav Tepeš   +3 more
doaj  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source