Results 111 to 120 of about 687,701 (312)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Sequence-based Measure for Assessing Drug-Side Effect Causal Relation from Electronic Medical Records [PDF]
, 2017 The recent prevalence of electronic medical records offers a new way to detect the drug-side effect causality. However, this approach faces with the problem of identifying the likely causal relation between drugs and side effects in a huge space of ...
Ho, Bao Tu, Dang, Tran Thai
core +1 more source
Estimating Causal Effects from Learned Causal Networks
The standard approach to answering an identifiable causal-effect query (e.g., P(Y|do(X)) given a causal diagram and observational data is to first generate an estimand, or probabilistic expression over the observable variables, which is then evaluated using the observational data.
Anna Raichev +3 more
openaire +2 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Nature and Science of SleepZuxing Wang,1,* Lili Chen,1,* Ruishi Kang,2,* Zhuowei Li,2 Jiangang Fan,2 Yi Peng,3,* Yunqi He,4,5 Xiaolong Zhao2 1Sichuan Provincial Center for Mental Health, Sichuan Provincial People’s Hospital, School of Medicine, University of ...
Wang Z +7 more
doaj
The Impact of Causal Ambiguity on Competitive Advantage and Rent Appropriation [PDF]
, 2010 We seek to develop the conceptual and practical understanding of causal ambiguity. Specifically we extend current thinking by setting out three types of causal ambiguity, based on whether firm resources are perceived to display linkage and/or ...
Ambrosini, Veronique +3 more
core +1 more source
On the Granularity of Causal Effect Identifiability
CoRRThe classical notion of causal effect identifiability is defined in terms of treatment and outcome variables. In this paper, we consider the identifiability of state-based causal effects: how an intervention on a particular state of treatment variables affects a particular state of outcome variables.
Yizuo Chen, Adnan Darwiche
openaire +2 more sources
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Frontiers in MedicineObjectiveThis study sought to identify candidate plasma proteins with potential causal associations with knee osteoarthritis (KOA) through Mendelian randomization, and to provide preliminary biological evidence through in vitro experiments.MethodsTwo ...
Wang Huang +3 more
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source