Results 111 to 120 of about 1,784,130 (283)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Causal relationships between gut microbiome and obstructive sleep apnea: a bi-directional Mendelian randomization

Frontiers in Microbiology
BackgroundPrevious studies have identified a clinical association between gut microbiota and Obstructive sleep apnea (OSA), but the potential causal relationship between the two has not been determined.
Liangfeng Liu, Guanwen He, Rong Yu, Bingbang Lin, Liangqing Lin, Rifu Wei, Zhongshou Zhu, Yangbin Xu, Yangbin Xu   +8 more
doaj   +1 more source

Causal network effect models

, 2022
The causal identification of network effects is fraught with theoretical and statistical difficulties. To guide social network researchers in choosing the right empirical strategy, this survey of network effect models (i) maps out the different types of network effects and levels of analysis, (ii) discusses data and measurement issues related to ...
openaire   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Causal effects and metabolites mediators between immune cell and risk of breast cancer: a Mendelian randomization study

Frontiers in Genetics
Introduction: The incidence and mortality of female breast cancer remain high, and the immune microenvironment of breast cancer has undergone significant alterations.
Ruijie Ming, Huan Wu, Hong Liu, Fangbiao Zhan, Xingan Qiu, Ming Ji   +5 more
doaj   +1 more source

Modified Causal Forests for Estimating Heterogeneous Causal Effects

SSRN Electronic Journal, 2018
Uncovering the heterogeneity of causal effects of policies and business decisions at various levels of granularity provides substantial value to decision makers. This paper develops new estimation and inference procedures for multiple treatment models in a selection-on-observables framework by modifying the Causal Forest approach suggested by Wager and
openaire   +3 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Estimating Causal Effect of Two-Dose COVID-19 Vaccination on Hospitalization

Journal of Biostatistics and Epidemiology
Objective: To estimate the effectiveness of two-dose COVID-19 vaccination in reducing hospitalization, accounting for complex confounding factors in observational studies.
Mohammad Taghi Shakeri, Mahboobeh Taherizadeh, Saeed Akhlaghi, Ehsan Mosa Farkhani   +3 more
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source