Results 131 to 140 of about 27,731,435 (252)

Michotte’s research on perceptual impressions of causality: a registered replication study

Royal Society Open Science
Michotte (Michotte A, 1946 La perception de la causalité. Louvain: Études de Psychologie. Michotte A, 1954 La perception de la causalité, 2nd éd. Louvain: Études de Psychologie. Michotte A, 1963 The perception of causality. (Transl. by TR Miles, E Miles).
Peter White
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The causal relationship between gut microbiota and lymphoma: a two-sample Mendelian randomization study

Frontiers in Immunology
BackgroundPrevious studies have indicated a potential link between the gut microbiota and lymphoma. However, the exact causal interplay between the two remains an area of ambiguity.MethodsWe performed a two-sample Mendelian randomization (MR) analysis to
Biyun Li, Yahui Han, Zhiyu Fu, Yujie Chai, Xifeng Guo, Shurui Du, Chi Li, Dao Wang   +7 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Investigation of the causal association between Parkinson’s disease and autoimmune disorders: a bidirectional Mendelian randomization study

Frontiers in Immunology
BackgroundTo date, an increasing number of epidemiological evidence has pointed to potential relationships between Parkinson’s disease (PD) and various autoimmune diseases (AIDs), however, no definitive conclusions has been drawn about whether PD is ...
Junyi Yang, Weiran Lin, Weiran Lin, Weiran Lin, Yumei Ma, Hui Song, Hui Song, Changqing Mu, Qian Wu, Chen Han, Jian Zhang, Jian Zhang, Xu Liu   +12 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Causal Inference in Comparative and International Education

All phenomena in the social sciences are shaped by a complex web of variables, and using data to detect patterns and trends in such variables is important.
Kameshwara, K., Gorman, E.
core   +2 more sources

The Causal Effect of Parents' Schooling on Children's Schooling - A Comparison of Estimation Methods [PDF]

We review the empirical literature that estimates the causal effect of parent’s schooling on child’s schooling, and conclude that estimates differ across studies.
Mikael Lindahl, Erik Plug, Helena Holmlund   +2 more
core  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source