Results 151 to 160 of about 687,701 (312)

The Causal Effect of Parents' Schooling on Children's Schooling - A Comparison of Estimation Methods [PDF]

We review the empirical literature that estimates the causal effect of parent’s schooling on child’s schooling, and conclude that estimates differ across studies.
Mikael Lindahl, Erik Plug, Helena Holmlund   +2 more
core  

Causal Effect Identification in Uncertain Causal Networks

, 2023
Causal identification is at the core of the causal inference literature, where complete algorithms have been proposed to identify causal queries of interest.
Vowels, Matthew J., Etesami, Jalal, Jamshidi, Fateme, Mokhtarian, Ehsan, Kiyavash, Negar, Akbari, Sina   +5 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Estimating the Heterogeneous Causal Effects of Parent–Child Relationships among Chinese Children with Oppositional Defiant Symptoms: A Machine Learning Approach

Behavioral Sciences
Oppositional defiant symptoms are some of the most common developmental symptoms in children and adolescents with and without oppositional defiant disorder.
Haiyan Zhou, Fengkai Han, Ruoxi Chen, Jiajin Huang, Jianhui Chen, Xiuyun Lin   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Causality of immune cells on primary sclerosing cholangitis: a bidirectional two-sample Mendelian randomization study

Frontiers in Immunology
BackgroundObservational studies have indicated that immune dysregulation in primary sclerosing cholangitis (PSC) primarily involves intestinal-derived immune cells.
Pu Wu, Pu Wu, Pu Wu, Sinan Xie, Sinan Xie, Sinan Xie, Yunshi Cai, Yunshi Cai, Yunshi Cai, Hu Liu, Hu Liu, Hu Liu, Yinghao Lv, Yinghao Lv, Yinghao Lv, Ying Yang, Ying Yang, Ying Yang, Yucheng He, Yucheng He, Yucheng He, Bangjie Yin, Bangjie Yin, Bangjie Yin, Tian Lan, Tian Lan, Tian Lan, Hong Wu, Hong Wu, Hong Wu   +29 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Causal Associations Between Chronic Obstructive Pulmonary Disease and Common Comorbidities: Evidence from Comprehensive Genetic Methods

International Journal of COPD
Jiadong Ji,1 Qian Zhao,1 Jie Yuan,2 Zhongshang Yuan,2 Nannan Gao3 1Institute for Financial Studies, Shandong University, Jinan, Shandong, People’s Republic of China; 2Department of Biostatistics, School of Public Health, Cheeloo College of Medicine ...
Ji J, Zhao Q, Yuan J, Yuan Z, Gao N
doaj