Results 151 to 160 of about 27,731,435 (252)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
International Journal of COPDJiadong Ji,1 Qian Zhao,1 Jie Yuan,2 Zhongshang Yuan,2 Nannan Gao3 1Institute for Financial Studies, Shandong University, Jinan, Shandong, People’s Republic of China; 2Department of Biostatistics, School of Public Health, Cheeloo College of Medicine ...
Ji J, Zhao Q, Yuan J, Yuan Z, Gao N
doaj
On Granger-causality and the effect of interventions in time series [PDF]
We combine two approaches to causal reasoning. Granger-causality, on the one hand, is popular in fields like econometrics, where randomised experiments are not very common.
Didelez, Vanessa, Eichler, Michael
core
RNA‐related functions of BRCA2 in transcription, replication, and genome stability
FEBS Letters, EarlyView.Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda +2 more
wiley +1 more source
EPR, Robustness and the Causal Markov Condition [PDF]
, 2007 It is still a matter of controversy whether the Principle of the Common Cause (PCC) can be used as a basis for sound causal inference. It is thus to be expected that its application to quantum mechanics should be a correspondingly controversial issue ...
San Pedro, Iñaki, Suárez, Mauricio
core
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
The causal effect of family difficulties during childhood on adult labour market outcomes [PDF]
Applying a propensity score matching approach to UK National Child Development Study, we find that experiencing family difficulties during childhood determines a negative and long-lasting impact on adult employment probabilities and wage.
Millemaci, Emanuele, Sciulli, Dario
core
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Non-causal explanation in science [PDF]
, 2013 Non-causal and causal explanation in science are unified under an extension of James Woodward's manipulationist account of causal explanation. Scientific explanation is about capturing and representing the modal structure of the world.
Pexton, Mark
core