Results 141 to 150 of about 687,701 (312)

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Estimating Causal Effect of Two-Dose COVID-19 Vaccination on Hospitalization

Journal of Biostatistics and Epidemiology
Objective: To estimate the effectiveness of two-dose COVID-19 vaccination in reducing hospitalization, accounting for complex confounding factors in observational studies.
Mohammad Taghi Shakeri, Mahboobeh Taherizadeh, Saeed Akhlaghi, Ehsan Mosa Farkhani   +3 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Association between the gut microbiota and diabetic nephropathy: a two-sample Mendelian randomization study

Renal Failure
Numerous studies have revealed a correlation between the risk of developing diabetic nephropathy (DN) and the gut microbiota (GM) composition. However, it remains uncertain whether the GM composition causes DN.
Wenjie Dong, Qiuyu Li, Lei Chen, Hui Tang, Kun Tu, Li Luo, Longyang Jiang, Yilan Huang   +7 more
doaj   +1 more source

Knowledge discovery in data and causal models in analytical informatics

, 2018
The methodology of inductive inference of causal models is briefly overviewed. We argue that causal networks, being recovered from data, are able to describe adequately a structure of influences in environment (object) at hand.
Balabanov, O.S.
core  

What triggers causal attributions? The impact of valence and subjective probability

, 1988
Bohner G, Bless H, Schwarz N, Strack F. What triggers causal attributions? The impact of valence and subjective probability. European Journal of Social Psychology.
Strack, Fritz, Schwarz, Norbert, Bless, Herbert, Bohner, Gerd ; https://orcid.org/   +3 more
core   +1 more source

Identifying Conditional Causal Effects

CoRR, 2012
This paper concerns the assessment of the effects of actions from a combination of nonexperimental data and causal assumptions encoded in the form of a directed acyclic graph in which some variables are presumed to be unobserved. We provide a procedure that systematically identifies cause effects between two sets of variables conditioned on some other ...
openaire   +3 more sources

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Role of inflammatory biomarkers in mediating the effect of lipids on spontaneous intracerebral hemorrhage: a two-step, two-sample Mendelian randomization study

Frontiers in Neurology
BackgroundSpontaneous intracerebral hemorrhage (sICH) is a form of stroke with high mortality rates and significant neurological implications for patients.
Mingsheng Huang, Yiheng Liu, Yuan Cheng, Weiran Dai   +3 more
doaj   +1 more source