Results 101 to 110 of about 1,784,130 (283)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Dagma-DCE: Interpretable, Non-Parametric Differentiable Causal Discovery

IEEE Open Journal of Signal Processing
We introduce Dagma-DCE, an interpretable and model-agnostic scheme for differentiable causal discovery. Current non- or over-parametric methods in differentiable causal discovery use opaque proxies of “independence” to justify the inclusion
Daniel Waxman, Kurt Butler, Petar M. Djuric   +2 more
doaj   +1 more source

A time series causal model [PDF]

Cause-effect relations are central in economic analysis. Uncovering empirical cause-effect relations is one of the main research activities of empirical economics.
Chen, Pu
core   +1 more source

Causal diffusions, causal Zeno effect and collision number

, 2009
We consider diffusion processes with the help of Markov random walk models. Especially the process of diffusion of a relativistic particle in a relativistic equilibrium system is considered. We interpret one of the results as causal Zeno effect for its similarity to quantum Zeno effect. Another problem we considered is about collision number. Basing on
Ren, Ji-Rong, Li, Ming-fan, Zhu, Tao
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Michotte’s research on perceptual impressions of causality: a registered replication study

Royal Society Open Science
Michotte (Michotte A, 1946 La perception de la causalité. Louvain: Études de Psychologie. Michotte A, 1954 La perception de la causalité, 2nd éd. Louvain: Études de Psychologie. Michotte A, 1963 The perception of causality. (Transl. by TR Miles, E Miles).
Peter White
doaj   +1 more source

Changes in Compulsory Schooling and the Causal Effect of Education on Health: Evidence from Germany [PDF]

In this paper we investigate the causal effect of years of schooling on health and health-related behavior in West Germany. We apply an instrumental variables approach using as natural experiments several changes in compulsory schooling laws between 1949
Jürges, Hendrik, Kemptner, Daniel, Reinhold, Steffen   +2 more
core  

Dynamic Causal Structure Discovery and Causal Effect Estimation

Proceedings of the 31st ACM SIGKDD Conference on Knowledge Discovery and Data Mining V.1
To represent the causal relationships between variables, a directed acyclic graph (DAG) is widely utilized in many areas, such as social sciences, epidemics, and genetics. Many causal structure learning approaches are developed to learn the hidden causal structure utilizing deep-learning approaches.
Jianian Wang, Rui Song
openaire   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Effects of Causal Determinism on Causal Learning Trajectories [PDF]

, 2020
Research on causal learning suggests that people are capable of learning nondeterministic causal relations, but might expectcausal relations to be deterministic in certain contexts. In two experiments, we demonstrated that peoples expectations ofcausal determinism are context-sensitive and can influence causal judgments in a sequential learning task ...
Dinh, Phuong (Phoebe), Danks, David
openaire