Results 101 to 110 of about 560,868 (267)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Genetic associations and potential mediators between psychiatric disorders and irritable bowel syndrome: a Mendelian randomization study with mediation analysis

Frontiers in Psychiatry
ObjectivePotential causal associations between psychiatric disorders and irritable bowel syndrome have been demonstrated in observational studies; however, these studies are susceptible to underlying confounding and reverse causation biases.
Tao Zhang, Yuzhu Chen, Xiaoang Li, Jindong Zhang, Liping Duan   +4 more
doaj   +1 more source

The potential causal effect of the pre-pregnancy dietary phytochemical index on gestational diabetes mellitus: a prospective cohort study [PDF]

Neda Heidarzadeh‐Esfahani, Javad Heshmati, Reihaneh Pirjani, Ashraf Moini, Mehrnoosh Shafaatdoost, Mahnaz Esmaeili, Azar Mardi-Mamaghani, Seyyed Mostafa Nachvak, Mahdi Sepidarkish   +8 more
openalex   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

A Novel Improvement of Feature Selection for Dynamic Hand Gesture Identification Based on Double Machine Learning

Sensors
Causal machine learning is an approach that combines causal inference and machine learning to understand and utilize causal relationships in data. In current research and applications, traditional machine learning and deep learning models always focus on
Keyue Yan, Chi-Fai Lam, Simon Fong, João Alexandre Lobo Marques, Richard Charles Millham, Sabah Mohammed   +5 more
doaj   +1 more source

Language Models as Causal Effect Generators [PDF]

Lucius Bynum, Kyunghyun Cho
openalex   +1 more source

CAUSAL MODELING OF THE EFFECT OF FOREIGN DIRECT INVESTMENT, INDUSTRY GROWTH AND ENERGY USE TO CARBON DIOXIDE EMISSIONS

, 2020
Warsono Warsono, Edwin Russel, Wamiliana Wamiliana, Mustofa Usman, Widiarti Widiarti, Faiz Ahmed Mohamed Elfaki   +5 more
openalex   +2 more sources

Adversarial balancing-based representation learning for causal effect inference with observational data [PDF]

, 2021
Xin Du, Lei Sun, Wouter Duivesteijn, Alexander Nikolaev, Mykola Pechenizkiy   +4 more
openalex   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Inferring the causal effect of work zones on crashes: Methodology and a case study

, 2021
Zhuoran Zhang, Burcu Akinci, Sean Qian
openalex   +1 more source