Results 141 to 150 of about 16,076,570 (308)
International Journal of COPDJiadong Ji,1 Qian Zhao,1 Jie Yuan,2 Zhongshang Yuan,2 Nannan Gao3 1Institute for Financial Studies, Shandong University, Jinan, Shandong, People’s Republic of China; 2Department of Biostatistics, School of Public Health, Cheeloo College of Medicine ...
Ji J, Zhao Q, Yuan J, Yuan Z, Gao N
doaj
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Causal effects of gut microbiota on multiple sclerosis: A two‐sample Mendelian randomization study
Brain and BehaviorBackground Gut microbiota alterations in multiple sclerosis (MS) patients have been reported in observational studies, but whether these associations are causal is unclear.
Dongren Sun +7 more
doaj +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Estimating Causal Effects in Partially Directed Parametric Causal Factor Graphs
Lifting uses a representative of indistinguishable individuals to exploit symmetries in probabilistic relational models, denoted as parametric factor graphs, to speed up inference while maintaining exact answers. In this paper, we show how lifting can be applied to causal inference in partially directed graphs, i.e., graphs that contain both directed ...
Luttermann, Malte +3 more
openaire +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
The moments of random variables are fundamental statistical measures for characterizing the shape of a probability distribution, encompassing metrics such as mean, variance, skewness, and kurtosis. Additionally, the product moments, including covariance and correlation, reveal the relationships between multiple random variables.
Kawakami, Yuta, Tian, Jin
openaire +2 more sources
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source