Results 161 to 170 of about 16,076,570 (308)

Causal Effect of Dietary Patterns on Cerebral Small Vessel Disease: A Mendelian Randomization Study. [PDF]

Food Sci Nutr
Zeng Y, Zhao Z, Liu H, Zeng Y, Xu S, Nie S.   +5 more
europepmc   +1 more source

Identifying Causal Effects [PDF]

, 2019
openaire   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Genetic Evidence Reveals Causal Effect of Circulating Proteome on Random Glucose: A Mendelian Randomization Study. [PDF]

J Diabetes Res
Shen Z, Xing X, Zhang X, Zhu J, Wang Y, Cai G.   +5 more
europepmc   +1 more source

Lagged Explanatory Variables and the Estimation of Causal Effect

Journal of Politics, 2017
Marc F. Bellemare, T. Masaki, Thomas B. Pepinsky   +2 more
semanticscholar   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

The causal effect of scoliosis on mental disorders: A two-sample Mendelian randomization study. [PDF]

Medicine (Baltimore)
Ren L, Fu S, Zhang B, Li Y, Yang Z, Rong M, Wang Y.   +6 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Causal Impact of Immune Phenotypes on Herpes Zoster and Postherpetic Neuralgia: Insights from Mendelian Randomization Analysis

Clinical, Cosmetic and Investigational Dermatology
Zhangren Yan,1 Dandan Shen,1 Xiaoqian Qiu,2 Bohua Ai,2 Chenxi Xiong2 1Department of Traditional Chinese Medicine Surgery, Hospital of Traditional Jiangxi University of Chinese Medicine, Nanchang, 330006, People’s Republic of China; 2Graduate School ...
Yan Z, Shen D, Qiu X, Ai B, Xiong C
doaj  

The role of metabolites in the causal effect of immune cell phenotypes on immunotherapy toxicity risk. [PDF]

Discov Oncol
Tang M, Mu F, Yan Z, Gong R, Cui C, Sun K, Zhao J, Wang J.   +7 more
europepmc   +1 more source