Results 41 to 50 of about 96,494 (250)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
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Prospective and retrospective causal inferences based on the potential outcome framework
Journal of Causal InferenceIn this article, we discuss both prospective and retrospective causal inferences, building on Neyman’s potential outcome framework. For prospective causal inference, we review criteria for confounders and surrogates to avoid the Yule–Simpson paradox and ...
Geng Zhi +4 more
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Interventional Approach for Path-Specific Effects
Journal of Causal Inference, 2017 Standard causal mediation analysis decomposes the total effect into a direct effect and an indirect effect in settings with only one single mediator.
Lin Sheng-Hsuan, VanderWeele Tyler
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FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
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A Kernel-Based Metric for Balance Assessment
Journal of Causal Inference, 2018 An important goal in causal inference is to achieve balance in the covariates among the treatment groups. In this article, we introduce the concept of distributional balance preserving which requires the distribution of the covariates to be the same in ...
Zhu Yeying +2 more
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The variance of causal effect estimators for binary v-structures
Journal of Causal Inference, 2022 Adjusting for covariates is a well-established method to estimate the total causal effect of an exposure variable on an outcome of interest. Depending on the causal structure of the mechanism under study, there may be different adjustment sets, equally ...
Kuipers Jack, Moffa Giusi
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FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
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Learning Heterogeneity in Causal Inference Using Sufficient Dimension Reduction
Journal of Causal Inference, 2019 Often the research interest in causal inference is on the regression causal effect, which is the mean difference in the potential outcomes conditional on the covariates. In this paper, we use sufficient dimension reduction to estimate a lower dimensional
Luo Wei, Wu Wenbo, Zhu Yeying
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Journal of Causal Inference, 2022 Recent studies have indicated that it is possible to protect individuals from HIV infection using passive infusion of monoclonal antibodies. However, in order for monoclonal antibodies to confer robust protection, the antibodies must be capable of ...
Jin Yutong, Benkeser David
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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