Results 51 to 60 of about 5,363 (277)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Structural network measures and their proposed interpretation for causal loop diagrams and intervention planning.

, 2016
Structural network measures and their proposed interpretation for causal loop diagrams and intervention planning.
Kayla de la Haye (568033), Steven Allender (305042), Jaimie McGlashan (3279522), Michael Johnstone (3279516), Doug Creighton (3279519)   +4 more
core   +1 more source

Utilizing Causal Loop Diagramming to Explore a Research and Evaluation Capacity Building Partnership

Frontiers in Public Health, 2022
The capacity to engage in research, evaluation and evidence-informed decision-making supports effective public health policy and practice. Little is known about partnership-based approaches that aim to build capacity across a system or how to evaluate ...
Rochelle Tobin, Gemma Crawford, Jonathan Hallett, Bruce Maycock, Roanna Lobo   +4 more
doaj   +1 more source

Qualitative Causal Loop Diagram: One Health Model Conceptualizing Brucellosis in Jordan

Systems, 2023
Background: Brucellosis is a serious public health problem distributed worldwide. Jordan has one of the highest incidences of brucellosis globally, mostly caused by infection with Brucella melitensis, which is associated with small, ruminant animals such as sheep.
Haitham Taha, Jo Durham, Carl Smith, Simon Reid   +3 more
openaire   +5 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Making Systems Thinking Public: Collaborative Construction, Revision and Use of Computer-based Causal Loop Diagrams

, 2022
To solve complex realworld problems in life science, it is important for students to adopt a systems approach. This study examined a 2-week unit that used computer-based causal loop diagramming to foster university students’ systems thinking about ...
Leung, JSC, Cheng, MMW, Chik, PYY
core  

Identification of a One Health Intervention for Brucellosis in Jordan Using System Dynamics Modelling

Systems, 2023
Brucellosis occurs because of a complex multisector system involving the interplay between animal production and human behavior. A better understanding of transmission dynamics helps pinpoint the most effective interventions to reduce human and animal ...
Haitham Taha, Carl Smith, Jo Durham, Simon Reid   +3 more
doaj   +1 more source

UNDERSTANDING THE DYNAMIC BEHAVIOUR OF THE AUSTRALIAN RETIREMENT VILLAGE INDUSTRY: A CAUSAL LOOP DIAGRAM

International Journal of Strategic Property Management, 2021
The retirement village industry in Australia has been accommodating an increasing number of residents in recent decades. However, a thorough understanding of the dynamic behaviour of the industry remains largely unknown, which prevents a better prediction of its future growth.
Bo Xia, Qing Chen, Jerry Walliah, Laurie Buys, Martin Skitmore, Connie Susilawati   +5 more
openaire   +7 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Evolving (dis)engagement: analyzing employees' responses to sustainability initiatives through causal loop diagrams

Frontiers in Sustainability
IntroductionThis study employed a systems thinking approach to explore the complex and dynamic interactions between sustainability initiatives, and employees' subsequent perceptions, attitudes, and behaviors.
Carolina Bettker Vasconcelos, Ane Sanchez-Zeziaga, Klaus Henning, Yvonne van der Meer   +3 more
doaj   +1 more source