Results 61 to 70 of about 1,284,492 (275)
Journal of Librarianship and Scholarly Communication, 2021 Almost 50% of scholarly articles are now open access in some form. This greatly benefits scholars at most institutions and is especially helpful to independent scholars and those without access to libraries.
Richard G. Dudley
doaj +2 more sources
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
International Journal of Strategic Property Management, 2021 The retirement village industry in Australia has been accommodating an increasing number of residents in recent decades. However, a thorough understanding of the dynamic behaviour of the industry remains largely unknown, which prevents a better prediction of its future growth.
Bo Xia +5 more
openaire +7 more sources
Systems, 2023 Brucellosis occurs because of a complex multisector system involving the interplay between animal production and human behavior. A better understanding of transmission dynamics helps pinpoint the most effective interventions to reduce human and animal ...
Haitham Taha +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Two loop vertices and tree level multicollinear limits in QCD [PDF]
, 2005 We present a summary of the methods required to solve loop-integrals and their reduction to Master Integrals. We then present the expansion in d = 4 - 2e of the Master Integrals required for the two loop massless vertex diagrams with three off-shell legs.
Birthwright, Thomas G. +2 more
core
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Effects of Instructional Guidance on Modeling Causal Loop Diagrams in Climate Change Education
Education SciencesClimate change education requires learners to understand complex systems and dynamic interdependencies, making systems modeling an important competence within education for sustainable development.
Nico Tuncel, Maik Beege, Werner Rieß
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source