Results 71 to 80 of about 5,363 (277)

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Convergent Microfinance Strategy: Combining Fintech and Conventional Methods to Enhance Rural Financial

Qubahan Academic Journal
Financial inclusion in rural areas continues to face challenges due to poor infrastructure, low digital literacy, and resistance to financial technology.
Sylviana Maya Damayanti , Acip Sutardi , Raden Aswin Rahadi , Arinda Mentari Putri , Aghnia Nadhira Aliya Putri , Rozan Hanifan   +5 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Developing capacity for learning community systems: Experiences from the 100 Million Healthier Lives SCALE Initiative

Learning Health Systems, 2022
Introduction This paper explores the capabilities that contribute to community transformation and the common pathways followed by communities in the 100 Million Healthier Lives SCALE (Spreading Community Accelerators through Learning and Evaluation ...
Tara Carr, Margaret Holly, Kristin Reed, Rumana Rabbani, Caroline Chandler, Brittany Cook, Paul Howard, Marianne McPherson, Becky Henry, Rohit Ramaswamy   +9 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Modelling interrelations between C-ITS impact categories: a system-dynamics approach using causal loop diagrams

European Transport Research Review
The growing number of connected vehicles has led to an increased focus on Vehicle-to-Everything (V2X) communication in the field of transport research.
Manuel Walch, Matthias Neubauer, Wolfgang Schildorfer, Alexander Schirrer   +3 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Energy Security within Malaysia’s Water-Energy-Food Nexus—A Systems Approach

Systems, 2019
While knowledge of energy security has been thorough and elaborate, understanding energy security within the context of the water-energy-food nexus, where substantial inter-sectoral causes and effects exist, is less established, more so for Malaysia ...
Andrew Huey Ping Tan, Eng Hwa Yap
doaj   +1 more source

Dynamics of the complex food environment underlying dietary intake in low-income groups: a systems map of associations extracted from a systematic umbrella literature review

International Journal of Behavioral Nutrition and Physical Activity, 2021
Background Inequalities in obesity pertain in part to differences in dietary intake in different socioeconomic groups. Examining the economic, social, physical and political food environment of low-income groups as a complex adaptive system – i.e.
Alexia D. M. Sawyer, Frank van Lenthe, Carlijn B. M. Kamphuis, Laura Terragni, Gun Roos, Maartje P. Poelman, Mary Nicolaou, Wilma Waterlander, Sanne K. Djojosoeparto, Marie Scheidmeir, Agnieszka Neumann-Podczaska, Karien Stronks, on behalf of the PEN Consortium   +12 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source