Results 71 to 80 of about 1,284,492 (275)

Causal Diagrams for Causal Inference: An Introduction [PDF]

, 2022
openIn ambito econometrico-statistico, per quantificare una relazione causa effetto è richiesto un dettagliato lavoro preliminare di conoscenza del contesto in cui si manifesta il fenomeno studiato, al fine di fornire argomenti utili ad attribuire una ...
BERTIN, NICOLA
core  

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Graph theory-based automated quantum algorithm for efficient querying of acyclic and multiloop causal configurations

Communications Physics
Quantum algorithms provide a promising framework in high-energy physics, in particular, for unraveling the causal configurations of multiloop Feynman diagrams by encoding Feynman propagators as qubits, a challenging task closely analogous to querying ...
Salvador A. Ochoa-Oregon, Juan P. Uribe-Ramírez, Roger J. Hernández-Pinto, Selomit Ramírez-Uribe, Germán Rodrigo   +4 more
doaj   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Learning Together for Groundwater Management: A Case of the Devnadi Basin, Nashik, Maharashtra, India

International Journal of the Commons
This paper documents the process of co-learning spaces for transdisciplinary learning for participatory groundwater and ecosystem management across research-practice-community collectives in the Devnadi River Basin, Sinnar Block of Nashik District in ...
Shuchi Vora
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Convergent Microfinance Strategy: Combining Fintech and Conventional Methods to Enhance Rural Financial

Qubahan Academic Journal
Financial inclusion in rural areas continues to face challenges due to poor infrastructure, low digital literacy, and resistance to financial technology.
Sylviana Maya Damayanti , Acip Sutardi , Raden Aswin Rahadi , Arinda Mentari Putri , Aghnia Nadhira Aliya Putri , Rozan Hanifan   +5 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Modelling interrelations between C-ITS impact categories: a system-dynamics approach using causal loop diagrams

European Transport Research Review
The growing number of connected vehicles has led to an increased focus on Vehicle-to-Everything (V2X) communication in the field of transport research.
Manuel Walch, Matthias Neubauer, Wolfgang Schildorfer, Alexander Schirrer   +3 more
doaj   +1 more source