Results 121 to 130 of about 353,766 (277)

Reviewing methodological approaches to dose-response modelling in complex interventions: insights and perspectives

BMC Medical Research Methodology
Background Understanding dose-response relationships is crucial in optimizing clinical outcomes, particularly in complex interventions such as psychotherapy.
Mollie Payne, Dominic Stringer, Ben Carter, Amy Hardy, Richard Emsley   +4 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

A spectral sampling algorithm in dynamic causal modelling for resting-state fMRI. [PDF]

Hum Brain Mapp, 2023
Xie Y, Zhang P, Zhao J.
europepmc   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Exploring Causal Factor in Highway–Railroad-Grade Crossing Crashes: A Comparative Analysis

Infrastructures
Identification of causal factors in traffic crashes has always been a significant challenge in road safety studies. Traditional crash prediction models are limited in elucidating the underlying causal mechanisms in road crashes.
Yubo Wang, Yubo Jiao, Liping Fu, Qiangqiang Shangguan   +3 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Dynamic Modelling Analysis on The Effectiveness of Coastal Land Resources for Aquaculture Activities Utilization

Journal of Natural Resources and Environmental Management
Coastal areas are considered biodiversity zones. This study aimed to analyze the effectiveness of land use on aquaculture productivity rate in coastal areas using a dynamic modeling analysis system.
Heri Ariadi, Benny Diah Madusari, Dewi Mardhiyana   +2 more
doaj   +1 more source

Graph-based real-time fault diagnostics [PDF]

A real-time fault detection and diagnosis capability is absolutely crucial in the design of large-scale space systems. Some of the existing AI-based fault diagnostic techniques like expert systems and qualitative modelling are frequently ill-suited for ...
Karsai, G., Padalkar, S., Sztipanovits, J.   +2 more
core   +1 more source

Causal modelling of heavy-tailed variables and confounders with application to river flow. [PDF]

Extremes (Boston), 2023
Pasche OC, Chavez-Demoulin V, Davison AC.   +2 more
europepmc   +1 more source