Results 101 to 110 of about 353,766 (277)

Causal Modeling

, 1993
Causal Models are like Dependency Graphs and Belief Nets in that they provide a structure and a set of assumptions from which a joint distribution can, in principle, be computed. Unlike Dependency Graphs, Causal Models are models of hierarchical and/or parallel processes, rather than models of distributions (partially) known to a model builder through ...
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Exploring Global Water Scarcity Dynamics Through Causal Discovery and Structural Causal Modelling

Earth's Future
Water scarcity represents a critical global challenge driven by diverse complex interactions between natural and anthropogenic factors. Long‐term water scarcity often results in depletion of water resources in so‐called water scarcity hotspots.
Myrthe Leijnse, Marc F. P. Bierkens, Niko Wanders   +2 more
doaj   +1 more source

Applications and reporting of causal inference modelling in infectious disease studies: A systematic review

Infectious Disease Modelling
Causal inference is increasingly employed in infectious disease (ID) epidemiology. Despite the increasing adoption of causal inference methods in infectious disease research, there has been no comprehensive review of their implementation trends ...
Yukiko Ezure, Mark Chatfield, David L. Paterson, Lisa Hall   +3 more
doaj   +1 more source

A PERSPECTIVE ON THE EFFECTS OF THE USE OF QUALITY COST INFORMATION ON QUALITY-RELATED LEARNING [PDF]

, 2018
The main purpose of this paper is to analyze the effects on quality-related learning resulting from the use of the quality cost information (QCI).
Casas Novas, Jorge, Saraiva, Margarida
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Econometric methodology for selecting explanatory factors for power consumption

MethodsX
A thorough and careful choice of inputs is the bedrock of all successful energy demand modelling. However, the choice of inputs in most research into fluctuations in electricity demand and its potential determinants is very often made by establishing a ...
Serge Guefano
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source