Results 91 to 100 of about 353,766 (277)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Proof and Uncertainty in Causal Claims
Exchanges, 2018 Causal questions drive scientific enquiry. From Hume to Granger, and Rubin to Pearl the history of science is full of examples of scientists testing new theories in an effort to uncover causal mechanisms. The difficulty of drawing causal conclusions from
Martine Jayne Barons, Rachel L Wilkerson
doaj
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Expressing business rules : a fact based approach : a thesis presented in partial fulfilment of the requirements for the degree of Master of Philosophy in Information Systems at Massey University, Palmerston North, New Zealand [PDF]
, 2004 Numerous industry surveys have suggested that many IT projects still end in failure. Incomplete, ambiguous and inaccurate specifications are cited as a major causal factor.
Hargreaves, Adrian John
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Mapping causal pathways with structural modes fingerprint for perovskite oxides
Machine Learning: Science and TechnologyCausality is innate to the determination of the fundamental mechanism controlling any physical phenomena. However, combining causality within the standard practices of computational modelling to understand structure-functionality connections is extremely
Ayana Ghosh, Saurabh Ghosh
doaj +1 more source
Réseaux bayésiens hiérarchiques avec variables latentes pour la modélisation des dépendances entre SNP: une approche pour les études d'association pangénomiques [PDF]
, 2010 Discover the genetic basis of common genetic diseases represents a public health issue. However this task presents several difficulties such as high data dimensionality and identification of the causal mutations.
Leray, Philippe +2 more
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Elements of sub-quantum thermodynamics: quantum motion as ballistic diffusion
, 2010 By modelling quantum systems as emerging from a (classical) sub-quantum thermodynamics, the quantum mechanical "decay of the wave packet" is shown to simply result from sub-quantum diffusion with a specific diffusion coefficient varying in time due to a ...
Fussy, Siegfried +3 more
core +1 more source