Results 81 to 90 of about 353,766 (277)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Semi-generative modelling: learning with cause and effect features [PDF]
, 2018 We consider a case of covariate shift where prior causal inference or expert knowledge has identified some features as effects, and show how this setting, when analysed from a causal perspective, gives rise to a semi-generative modelling framework: P(Y ...
Von Kügelgen, Julius
core +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
The Role of Social Capital in Economic Development. Investigating the Causal Nexus through Structural Equations Models [PDF]
This paper carries out an empirical assessment of the causal nexus connecting social capital’s diverse aspects to the “quality” of economic development in Italy. The analysis accounts for three main social capital dimensions (i.e.
Fabio Sabatini
core +3 more sources
Neural Masses and Fields in Dynamic Causal Modelling
Frontiers in Computational Neuroscience, 2013 Dynamic causal modelling (DCM) provides a framework for the analysis of effective connectivity among neuronal subpopulations that subtend invasive (electrocorticograms and local field potentials) and non-invasive (electroencephalography and ...
Rosalyn J Moran +3 more
doaj +1 more source
, 2007 Kravchenko (2007) suggests replacing Turing’s suggested method for explaining cognizers’ cognitive capacity through autonomous robotic modelling by ‘autopoeisis, Maturana’s extremely vague metaphor for the relations and interactions among organisms and ...
Harnad, Stevan
core
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
DAG: method for causal modelling in epidemiological research
Journal of the College of Community Physicians, 2018 No abstract ...
Anuji Gamage, Chrishantha Abeysena
doaj +1 more source
Building development cost drivers in the New Zealand construction industry : a multilevel analysis of the causal relationships : a thesis submitted in fulfilment of the requirements for the degree of Doctor of Philosophy (PhD) in Construction, School of Engineering & Advanced Technology, Massey University, Albany, New Zealand [PDF]
, 2018 Building development cost is influenced by a raft of complex factors which range from project characteristics to the operating environment and external dynamics. It is not yet clearly understood how these factors interact with each other and individually
Zhao, Linlin
core