Results 41 to 50 of about 271,409 (255)
Fallibilism and Ontology in Tuukka Kaidesoja’s Critical Realist Social Ontology
Journal of Social Ontology, 2015 This article addresses Tuukka Kaidesoja’s critique of the philosophical presuppositions of Roy Bhaskar’s theories of critical realism. The article supports Kaidesoja’s naturalistic approach to the philosophy of the social sciences, including the field ...
Daniel Little
doaj
Machine Learning-Based Diagnosis Method for Intermittent Open-Circuit Faults Affecting IGBTs in Traction Inverters [PDF]
Jisuanji gongchengA traction inverter is the core device in a train power system, and its power semiconductor, the Insulated Gate Bipolar Transistor (IGBT), is prone to random intermittent open-circuit faults under long-term vibrations and complex operating conditions ...
QIAN Cunyuan, CHEN Guoqiang, LI Zhupei
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Frontiers in Genetics, 2014 When analyzing the data arising from exome or whole-genome sequencing studies, window-based tests, i.e. tests that jointly analyze all genetic data in a small genomic region, are very popular.
ChangJiang eXu +5 more
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
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Applied SciencesThe integration of renewable energy sources (RESs) into electric power systems introduces new challenges for system operation, reliability, and emergency management.
Na Wang +6 more
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Capabilities as causal powers [PDF]
Cambridge Journal of Economics, 2006 The author argues that Sen's capability approach is primarily a philosophical under-labouring exercise aimed at elaborating certain central economic categories, and that the philosophical and methodological underpinnings of Sen's approach are radically different from those of contemporary welfare economics and mainstream economic practice. Sen's notion
openaire +3 more sources