Results 121 to 130 of about 6,601,325 (263)

Relationship between the causal and regression equations for radiating pathway.

, 2018
Relationship between the causal and regression equations for radiating pathway.
Vibishan B. (5848271), Manawa Diwekar-Joshi (5848274), Anagha Pund (5848268), Suraj Chawla (5848265), Shubhankar Kulkarni (4325881), Milind Watve (2617015)   +5 more
core   +1 more source

Causal relationship between hypothyroidism and ulcerative colitis: a bidirectional Mendelian randomization study

BMC Gastroenterology
Objective Ulcerative colitis (UC) and Hashimoto’s thyroiditis frequently cooccur in patients with multiple autoimmune conditions, but the specific association between UC and hypothyroidism is unknown.
Yumeng Yang, Jianhui Li, Xin Wang, Jing Ma   +3 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Causal Effects of Gut Microbiome on Tinnitus: A Mendelian Randomization Study

Journal of Multidisciplinary Healthcare
Qiang Zeng,1 Wei Xie,2 Huaqian Dong,2 Xing Liu,1 Shuai Shao,1 Li Chen,1 Wenwen Zhang1 1School of Nursing, Guizhou University of Traditional Chinese Medicine, Guiyang, 550002, People’s Republic of China; 2Department of Nursing, the First Affiliated ...
Zeng Q, Xie W, Dong H, Liu X, Shao S, Chen L, Zhang W   +6 more
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Causal relationship between sleep traits and erectile dysfunction: evidence from Mendelian randomization analysis

Introduction Although several observational studies have explored the association between sleep traits and the risk of erectile dysfunction (ED), it remains controversial.
Zeqiao Xu, Xiaojia Guo, Jian Zhang, Qingqiang Gao, Leilei Zhu   +4 more
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

NEW EVIDENCE ON THE CAUSAL LINKAGES BETWEEN FOREIGN DIRECT INVESTMENT, EXPORTS AND IMPORTS IN MALAYSIA [PDF]

By extending Wong and Tang’s (2007) study, this study aims to further explore the causal relations between FDI (foreign direct investment), exports and imports. There is a unique long-run causal relationship running from exports as well as imports to FDI.
Koi Nyen Wong, Tuck Cheong Tang
core  

A Mendelian Randomization Study: Roles of Gut Microbiota in Sepsis – Who is the Angle?

Polish Journal of Microbiology
Gut microbiota (GM) is a crucial underlying player during sepsis pathogenesis. However, the causal relationship is unclear and remains to be determined. A two-sample Mendelian randomization study was implemented.
Bian Yeping, Xu Jian, Deng Xiaojing, Zhou Suming   +3 more
doaj   +1 more source