Results 111 to 120 of about 6,350,077 (307)

Causal Relationship Between Intelligence, Noncognitive Education, Cognition and Urinary Tract or Kidney Infection: A Mendelian Randomization Study [PDF]

Shuai Fu,* Qiang Li,* Li Cheng, Sheng Wan, Quan Wang, Yonglong Min, Yanghao Xie, Huizhen Liu, Taotao Hu, Hong Liu, Weidong Chen, Yanmin Zhang, Fei Xiong Department of Nephrology, Wuhan No.
Wan S, Liu H, Fu S, Hu T, Wang Q, Xie Y, Min Y, Zhang Y, Chen W, Cheng L, Li Q, Xiong F   +11 more
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Genetically predicted gut microbiota mediate the association between plasma lipidomics and primary sclerosing cholangitis

BMC Gastroenterology
Background Primary sclerosing cholangitis (PSC) is a complex disease with pathogenic mechanisms that remain to be elucidated. Previous observational studies with small sample sizes have reported associations between PSC, dyslipidemia, and gut microbiota ...
Jie Zhou, Dagang Zhu, Yixin Xu, Chao Chen, Kun Wang   +4 more
doaj   +1 more source

Causal Relationship Between Blood Triglyceride Levels and Age Spots: A Mendelian Randomization Analysis

, 2023
Hongtao Liu,1 Shaopeng Ming2 1Clinical Medical School, Guangxi Health Science College, Nanning, 530011, People’s Republic of China; 2Anesthesiology Department, The Second Affiliated Hospital of Guangxi Medical University, Nanning, 530007, People’s ...
Liu H, Ming S
core  

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Investigating causal associations between pneumonia and lung cancer using a bidirectional mendelian randomization framework

BMC Cancer
Background Pneumonia and lung cancer are both major respiratory diseases, and observational studies have explored the association between their susceptibility. However, due to the presence of potential confounders and reverse causality, the comprehensive
Lujia Song, Dongsheng Wu, Jiayang Wu, Jiexi Zhang, Weimin Li, Chengdi Wang   +5 more
doaj   +1 more source

Causal Relationship between Education, Carbon Dioxide ( ) Emission and Economic Growth in Bangladesh [PDF]

, 2014
The purpose of this study is to test the relationship among education environmental pollution and economic growth in Bangladesh Perhaps this is the first research done using time series data for 37 years from 1974-2010 Vector Error Correction ...
Mirza Md. Moyen Uddin
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Bitcoin: a Ponzi scheme or an emerging inflation-fighting asset?

Technological and Economic Development of Economy
Under the dual impact of the COVID-19 pandemic and the Russian-Ukrainian conflict, the excessive stimulation of monetary policy continuously pushes up global inflation (INF). Therefore, this article explores whether Bitcoin can serve as a safe haven for
Fangying Liu, Chi Wei Su, Meng Qin, Muhammad Umar   +3 more
doaj   +1 more source