Results 121 to 130 of about 144,990 (292)

ALCOHOL AS A FACTOR IN THE CAUSATION OF DETERIORATION IN THE INDIVIDUAL AND THE RACE

, 1905
W. McAdam Eccles
openalex   +2 more sources

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Applying causal reasoning to investigate multicausality in microbial systems

Ecosphere
Microbial communities contribute to many essential ecological functions, from carbon cycling in soil to healthy functioning of the human body. Yet, determining how the make‐up of microbial communities is causally linked to a particular function remains a
Teal S. Potter, Zachary Zalewski, Max Miao, Cassandra Allsup, Kathleen M. Thompson, Daniel Hayden, Isabelle George, Richard A. Lankau, Emily W. Lankau   +8 more
doaj   +1 more source

Primary Anaesthetic Deaths in Western Australia from 1985–2008: Causation and Preventability [PDF]

, 2013
N. M. Gibbs, P. Rodoreda
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Taking Seriously the Metaphysics of Mental Causation: A Nonreductivist Account

, 2013
Matthew Michael Konig
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Uncovering What, Why and How: A Comprehensive Benchmark for Causation Understanding of Video Anomaly [PDF]

Hang Du, Sicheng Zhang, Binzhu Xie, Guoshun Nan, Jiayang Zhang, Junrui Xu, Hangyu Liu, Sicong Leng, Jiangming Liu, Hehe Fan, Dajiu Huang, Jing Feng, Linli Chen, Can Zhang, Xuhuan Li, Hao Zhang, Jianhang Chen, Qimei Cui, Xiaofeng Tao   +18 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Brain structure and problematic alcohol use: a test of plausible causation using latent causal variable analysis

, 2021
Alexander S. Hatoum, Emma C. Johnson, Arpana Agrawal, Ryan Bogdan   +3 more
openalex   +2 more sources