Results 51 to 60 of about 2,059,704 (313)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023 [PDF]

Background: Timely and comprehensive analyses of causes of death stratified by age, sex, and location are essential for shaping effective health policies aimed at reducing global mortality. The Global Burden of Diseases, Injuries, and Risk Factors Study (
Mario D'Oria, GBD 2023 Causes of Death Collaborators, Simon I. Hay, Luca Cegolon   +3 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Intracranial injuries in the autopsy material of the Department of Forensic Medicine of the Medical University of Lodz with analysis of anatomical lesions caused by traumatic brain injuries

Translational Research in Anatomy
Background: In 2022, 408 autopsies were performed in the Department of Forensic Medicine of the Lodz Medical University, of which as many as 82 concerned deaths with intracranial injuries, which represents about 20 % of all performed autopsies.
Anna Smędra, Jarosław Berent, Edward Clarke, Jakub Dębski, Andrzej Żytkowski   +4 more
doaj   +1 more source

Mortality risk and causes of death in patients with non-cystic fibrosis bronchiectasis

Respiratory Research, 2019
Background All-cause mortality risk and causes of death in bronchiectasis patients have not been fully investigated. The aim of this study was to compare the mortality risk and causes of death between individuals with bronchiectasis and those without ...
Sooim Sin, Seo Young Yun, Jee Min Kim, Chang Min Park, Jaeyoung Cho, Sun Mi Choi, Jinwoo Lee, Young Sik Park, Sang-Min Lee, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Chang-Hoon Lee   +12 more
doaj   +1 more source

A Cross-sectional Study on the Pattern of Skull Fractures in Fatal Two-wheeler Road Traffic Accidents at a Tertiary Care Hospital in Northeastern India [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Death due to Road Traffic Accidents (RTA) is one of the leading causes of mortality and morbidity in a developing country like India. As there is a paucity of literature on the nature and type of injuries in RTAs in the locality of Upper ...
Nabajit Barman, Gobil Thapa, Swagata Dowerah   +2 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

India and the problem of “needless autopsies”

Egyptian Journal of Forensic Sciences, 2018
The primary aim of autopsy is to ascertain the cause of death. The autopsies performed worldwide are mostly medico-legal or clinical. In India, 'needless autopsies' are conducted widely causing waste of already limited resources.
Tanuj Kanchan, Kewal Krishan, Alok Atreya, Neelam Dehal   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Competing causes of death: A death certificate study [PDF]

Journal of Clinical Epidemiology, 1997
Despite the widespread interest in competing causes of death, empirical information on interrelationships between causes of death is scarce. We have used death certificate information to estimate the prevalence of competing causes of death at the moment of dying from specific underlying causes of death.In a stratified sample of 5975 deaths occurring in
Mackenbach, J. P., Kunst, A. E., Lautenbach, H., Oei, Y. B., Bijlsma, F.   +4 more
openaire   +4 more sources