Results 61 to 70 of about 4,282,769 (355)

Competing causes of death: A death certificate study [PDF]

Journal of Clinical Epidemiology, 1997
Despite the widespread interest in competing causes of death, empirical information on interrelationships between causes of death is scarce. We have used death certificate information to estimate the prevalence of competing causes of death at the moment of dying from specific underlying causes of death.In a stratified sample of 5975 deaths occurring in
Mackenbach, J. P., Kunst, A. E., Lautenbach, H., Oei, Y. B., Bijlsma, F.   +4 more
openaire   +4 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Fatality from COVID-19 does not affect palliative care duration among patients with advanced cancer: a retrospective cohort study [PDF]

Einstein (São Paulo)
Objective: This study aimed at investigating the extent to which COVID-19-induced fatalities affect the duration of palliative care among patients with advanced cancer.
Rafael Tavares Jomar, Jéssica Thaís Nascimento Marques, Livia Costa de Oliveira, Gelcio Luiz Quintella Mendes, Daianny Arrais de Oliveira da Cunha, Raphael Mendonça Guimarães   +5 more
doaj   +1 more source

Cause of death for patients with breast cancer: discordance between death certificates and medical files, and impact on survival estimates

Archives of Public Health, 2021
Background Registration and coding of cause of death is prone to error since determining the exact underlying condition leading directly to death is challenging.
Hava Izci, Tim Tambuyzer, Jessica Vandeven, Jérôme Xicluna, Hans Wildiers, Kevin Punie, Nynke Willers, Eva Oldenburger, Els Van Nieuwenhuysen, Patrick Berteloot, Ann Smeets, Ines Nevelsteen, Anne Deblander, Harlinde De Schutter, Patrick Neven, Geert Silversmit, Freija Verdoodt   +16 more
doaj   +1 more source

Skeletal Deformities in Osterix-Cre;Tgfbr2f/f Mice May Cause Postnatal Death [PDF]

, 2021
Kara N. Corps, Monica Stanwick, Juliann Rectenwald, Andrew Kruggel, Sarah B. Peters   +4 more
openalex   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

All-cause and cause-specific mortality in individuals with zero and minimal coronary artery calcium: A long-term, competing risk analysis in the Coronary Artery Calcium Consortium. [PDF]

, 2020
Background and aimsThe long-term associations between zero, minimal coronary artery calcium (CAC) and cause-specific mortality are currently unknown, particularly after accounting for competing risks with other causes of death.MethodsWe evaluated 66,363 ...
Berman, Daniel S, Blaha, Michael J, Blankstein, Ron, Blumenthal, Roger S, Budoff, Matthew J, Cainzos-Achirica, Miguel, Dardari, Zeina, Dzaye, Omar, Michos, Erin D, Miedema, Michael D, Nasir, Khurram, Rozanski, Alan, Rumberger, John A, Shaw, Leslee J   +13 more
core  

Structural imaging biomarkers of sudden unexpected death in epilepsy. [PDF]

, 2015
Sudden unexpected death in epilepsy is a major cause of premature death in people with epilepsy. We aimed to assess whether structural changes potentially attributable to sudden death pathogenesis were present on magnetic resonance imaging in people who ...
Balestrini, Simona, Diehl, Beate, Duncan, John S, Harper, Ronald M, Koepp, Matthias, Lhatoo, Samden, Micallef, Caroline, Sander, Josemir W, Scott, Catherine, Sisodiya, Sanjay M, Thom, Maria, Vos, Sjoerd B, Wandschneider, Britta   +12 more
core   +3 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Characteristics and direct causes of death in severely ill patients admitted to a neurology department

Frontiers in Neurology
IntroductionThe study aimed to analyze the characteristics of patients admitted to the neurology department of a tertiary hospital who subsequently died, focusing on those with high disease severity.Materials and methodsWe conducted a retrospective ...
Da Heui Lee, Seok Young Jeong, Byoung-Soo Shin, Byoung-Soo Shin, Hyun Goo Kang, Hyun Goo Kang   +5 more
doaj   +1 more source