Results 131 to 140 of about 2,926,770 (304)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
BMC Health Services ResearchBackground Healthcare workers face health risks, including stress, burnout, and communicable diseases, leading to higher mortality rates. However, excess mortality diminishes with better disease control and lifestyle factors.
Povilas Kavaliauskas +4 more
doaj +1 more source
Adult mortality in a rural area of Senegal [PDF]
This study provides original estimates of adult mortality in Mlomp, a rural population of Senegal which has been monitored for twenty years. Causes of death are assessed through verbal autopsies which are completed by medical information. Between ages 15
Gilles Pison, Géraldine Duthé
core
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Macroeconomic Changes and Mortality in Mexico [PDF]
While previous studies examine how the business cycle affects mortality in developed countries, less is known about this relationship in developing countries.
Fidel Gonzalez, Troy Quast
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
What do Portuguese people die of? [PDF]
, 2018 Nowadays, in developed countries as Portugal, deaths are essentially concentrated at old and very old ages, but it is still rather important to identify main causes of death (CODs).
Ribeiro, Filipe
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Seasonal waves of influenza and cause-specific mortality in Germany
Open Medicine, 2012 Huy Christina +3 more
doaj +1 more source