Results 141 to 150 of about 1,173,637 (219)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Long-term mortality and causes of death after venous thromboembolism: findings from the Atherosclerosis Risk in Communities Cohort Study. [PDF]

J Thromb Haemost
Kamin Mukaz D, Li A, Guan W, Cao R, Huo L, Tang W, Lutsey PL, Zakai NA, Folsom AR, Cushman M.   +9 more
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Mortality risk and causes of death in exogenous Cushing's syndrome: a systematic review and meta-analysis.

J Clin Endocrinol Metab
Limumpornpetch P, Stewart PM, Pujades-Rodriguez M, Baxter PD, Tiganescu A, Nyaga VN, Morgan AW.   +6 more
europepmc   +1 more source

Prevalence, incidence, mortality and causes of death in a large cohort of patients with rheumatoid arthritis: an Italian population-based study. [PDF]

RMD Open
Osele AG, Zen M, Salmaso L, Amidei CB, Fedeli U, Giollo A, Ragno D, Vesentini F, Salvato M, Ramonda R, Saia M, Doria A.   +11 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Quality of causes of death data in Minnesota from 2011 to 2021 - A descriptive analysis of the usage and correlates of garbage codes. [PDF]

Public Health Pract (Oxf)
Karnik H, Levin Z, Lasway J, Leider JP, Wrigley-Field E.   +4 more
europepmc   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Prospective systematic classification of causes of death in the course of multiple myeloma. [PDF]

Blood Cancer J
Jin JX, Besemer B, Yilmaz B, Hänel M, Fenk R, Bertsch U, Gu KJ, Hanoun C, Blau IW, Mann C, Scheid C, Schroers R, von Metzler I, Hensel M, Klein EM, Hoffmann M, Lutz C, Riesenberg H, Martens UM, Michel CS, Kunz C, Shumilov E, Gezer D, Holderried TAW, Trautmann-Grill K, Müller-Tidow C, Weisel KC, Raab MS, Salwender HJ, Goldschmidt H, Mai EK.   +30 more
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source