Results 151 to 160 of about 2,938,549 (351)

Which features of thin melanomas make them more likely to cause death [PDF]

, 2020
Magdalena Claeson, Peter D. Baade, Susan D. Brown, H. Peter Soyer, B. Mark Smithers, A.C. Green, David C. Whiteman, Kiarash Khosrotehrani   +7 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Beyond the underlying cause of death: an algorithm to study multi-morbidity at death

Population Health Metrics
Background In countries with high life expectancy, a growing share of the population is living with several diseases, a situation referred to as multi-morbidity.
Francesco Grippo, Luisa Frova, Marilena Pappagallo, Magali Barbieri, Sergi Trias-Llimós, Viviana Egidi, France Meslé, Aline Désesquelles   +7 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Seasonal waves of influenza and cause-specific mortality in Germany

Open Medicine, 2012
Huy Christina, Kuhn Dorothee, Schneider Sven, Zöllner Iris   +3 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Review of sheep mortality in the Ethiopian highlands, 1982-86 [PDF]

, 2011
Analyses the frequency and causes of deaths observed during 1982-86 in sheep flocks around Debre Berhan, Ethiopia. Includes data on annual crude death rates, causes of mortality, frequency, age at death, and seasonal crude death ...
Degefa, M., Kasali, O.B., Njau, B.C., Scholtens, R.G.   +3 more
core  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

A Study on Regional Differentials in Death Caused by Suicide in South Korea [PDF]

, 2007
Eunok Park, Mi Yeol Hyun, Chang In Lee, Eun Joo Lee, Seong Chul Hong   +4 more
openalex   +1 more source

Prevalence, underlying causes, and preventability of sepsis-associated mortality in US acute care hospitals [PDF]

, 2019
Importance: Sepsis is present in many hospitalizations that culminate in death. The contribution of sepsis to these deaths, and the extent to which they are preventable, is unknown.
Anderson, Deverick J, Dantes, Raymund B, Epstein, Lauren, Hamad, Yasir, Jones, Travis M, Klompas, Michael, O\u27Brien, Cara, Pande, Anupam, Rhee, Chanu, Varon, Jack, Warren, David K   +10 more
core   +1 more source