Results 161 to 170 of about 1,145,953 (258)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Mortality and causes of death after surgery for chronic subdural hematoma: a post hoc study of the FINISH randomized trial. [PDF]

Acta Neurochir (Wien)
Tommiska P, Knuutinen O, Lönnrot K, Luoto T, Leinonen V, Koivisto T, Tetri S, Posti JP, Raj R, FINISH study group.   +9 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Causes of death and types of injuries of avalanche fatalities based on forensic data: a scoping review. [PDF]

Resusc Plus
Romy C, Eidenbenz D, Grabherr S, Zafren K, Jaques C, Hall N, Pasquier M.   +6 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Mortality and Causes of Death in Patients With <i>Mycobacterium avium</i> Complex Isolates Through 28 Years. [PDF]

Open Forum Infect Dis
Dahl VN, Pedersen AA, Johansen IS, Ibsen MH, Fløe A, Løkke A, Hilberg O, Andersen AB, Wejse CM, Lillebaek T.   +9 more
europepmc   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

A hierarchy of causes of death in senescent C. elegans

Wang H, Kern CC, Nguyen Hong C, Saez Allende A, Qiao J, Zhang A, Fan Y, Ezcurra M, Gems D.   +8 more
europepmc   +1 more source

Reversible causes of death and the potential benefit of invasive emergency techniques in paediatric and adolescent trauma: a 12-years retrospective forensic analysis. [PDF]

BMC Emerg Med
Malolepszy L, Heidl S, Markmann M, Zajonz TS, Schneider N, Koch C, Hartwig S, Sander M, Schneck E.   +8 more
europepmc   +1 more source