Results 161 to 170 of about 60,250 (276)

Polydatin Protects Against the Formation of PPE‐Induced Abdominal Aortic Aneurysms in Mice by Activating Nuclear Factor Erythroid 2‐Related Factor 2

Drug Development Research, Volume 87, Issue 1, February 2026.
ABSTRACT Sudden death resulting from abdominal aortic aneurysm (AAA) rupture is a highly fatal cardiovascular condition. There remains an urgent need to identify innovative therapeutic strategies capable of decelerating AAA progression and rupture. Although polydatin (PLD) has been consistently shown to exert potent anti‐inflammatory effects in diverse
Zikang Liu, Jinyi Zhu, Qian Zhou, Haiyun Qian, Fenghe Cui   +4 more
wiley   +1 more source

Absence of Caveolin-1 P132L Mutation in Egyptian Breast Cancer Patients [PDF]

Mohamed Hosney, Salwa Sabet, Mohamed El‐Shinawi, Mona Mostafa Mohamed   +3 more
openalex   +1 more source

Tumor‐Associated Macrophages as Therapeutic Targets: Deciphering Interaction Networks and Advancing Clinical Translation

MedComm, Volume 7, Issue 2, February 2026.
Tumor‐associated macrophages are the most abundant immune cells in the tumor microenvironment, driving malignant progression and treatment resistance. This review summarizes the protumor mechanisms of TAMs (including phagocytosis modulation, metabolic reprogramming, exosomal communication, and immune interactions), evaluates three major strategies ...
Wurihan Bao, Xiaojie Qu, Yiqi Wang, Dan Huang, Huiling Zhang, Mingyuan Dong, Han Sun, Zhaogang Yang, Xuefeng Li   +8 more
wiley   +1 more source

Short-Term Administration of a Cell-Permeable Caveolin-1 Peptide Prevents the Development of Monocrotaline-Induced Pulmonary Hypertension and Right Ventricular Hypertrophy [PDF]

, 2006
Jean-François Jasmin, Isabelle Le Mercier, Jocelyn Dupuis, Herbert B. Tanowitz, Michael P. Lisanti   +4 more
openalex   +1 more source

Identifying the role of caveolin-1 and caveolin-2 in cancer cell proliferation and cancer drug resistance [abstract] [PDF]

, 2006
only availableFaculty Mentor: Dr. Grzegorz Sowa, Medical Pharmacology and PhysiologyCaveolae are flask-shaped invaginations of the plasma membrane. Caveolins are the major protein component building these caveolae.
Myears, Hillary E.
core  

Overexpression of Transferrin Receptor in Esophageal Squamous Cell Cancer Suggests Poor Prognosis and Potential Therapy

Cancer Science, Volume 117, Issue 2, Page 393-406, February 2026.
This study aimed to evaluate transferrin receptor (TfR) expression in human esophageal squamous cell cancer (ESCC) specimens and investigate the correlation between TfR overexpression and clinicopathological characteristics. Furthermore, we explored the potential of targeting iron metabolism pathways as a novel therapeutic strategy for ESCC.
Naoki Ikenaga, Tsuyoshi Takahashi, Koji Tanaka, Satoshi Serada, Minoru Fujimoto, Kota Momose, Kotaro Yamashita, Tomoki Makino, Takuro Saito, Kazuyoshi Yamamoto, Yukinori Kurokawa, Kiyokazu Nakajima, Tomomi Fujii, Eiichi Morii, Tetsuji Naka, Hidetoshi Eguchi, Yuichiro Doki   +16 more
wiley   +1 more source

PTRF Confers Melanoma‐Acquired Drug Resistance Through the Upregulation of EGFR

Cell Proliferation, Volume 59, Issue 2, February 2026.
The upregulation of PTRF, a critical caveolar component, and the concomitant increase in caveolae number potentiate cellular proliferation and survival pathways, thereby contributing to melanoma drug resistance. ABSTRACT Melanoma is the most serious type of skin cancer. About half of all melanomas have activating BRAF mutations.
Miao Wang, Ying Cao, Chengcheng Ren, Ke Wang, Yaxiang Wang, Xiaoying Wu, Jian Mao, Qian Liang, Qian Zhang, Hezhe Lu, Xiaowei Xu, Yu‐Sheng Cong   +11 more
wiley   +1 more source

MSC‐Derived Secretome and Exosomes in Dermatology: Mechanisms, Therapeutic Opportunities, and Scientific Challenges—A Narrative Review

International Journal of Dermatology, Volume 65, Issue 2, Page 257-272, February 2026.
ABSTRACT Mesenchymal stromal cells (MSCs) exert their effects primarily through paracrine signaling via soluble factors and extracellular vesicles (EVs), especially exosomes. These acellular components offer regenerative and immunomodulatory benefits with fewer safety and logistical constraints than cell‐based therapies.
Marcela da Costa Pereira Cestari, Reinaldo Falavigna Tovo, Daniela Franco Bueno   +2 more
wiley   +1 more source

Myopathy With Exercise‐Induced Intolerance due to Novel Biallelic Variants in OBSCN—A Clinical, Morphological and Molecular Analysis

Neuropathology and Applied Neurobiology, Volume 52, Issue 1, February 2026.
The phenotype of OBSCN variants consists of exercise intolerance ranging from myalgia and cramps to rhabdomyolysis. Symptoms are mainly induced by high‐intensity sports. Molecular analysis showing a deregulation of muscle processes associated with Ca2+ regulation, extrasarcolemmal integrity and autophagy emphasised the critical role of obscurin in ...
Heidrun H. Krämer‐Best, Marlen C. Reis, Andreas Hentschel, Michaela Weiß, Alexander Schaiter, Klaus‐Dieter Böhm, Andreas Roos, Dagmar Nolte, Anne Schänzer   +8 more
wiley   +1 more source

Cooperative Role of Caveolin-1 and C-Terminal Src Kinase Binding Protein in C-Terminal Src Kinase-Mediated Negative Regulation of c-Src [PDF]

, 2011
Aaron T. Place, Zhenlong Chen, Farnaz R. Bakhshi, Guoquan Liu, John P. O’Bryan, Richard D. Minshall   +5 more
openalex   +1 more source