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Assessing the Prognostic Value of Cytoplasmic and Stromal Caveolin-1 in Early Triple-Negative Breast Cancer Undergoing Neoadjuvant Chemotherapy. [PDF]
Teruel I +23 more
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Caveolin‐1 in oncogenic metabolic symbiosis
International Journal of Cancer, 2020Metabolic phenotypes of cancer cells are heterogeneous and flexible as a tumor mass is a hurriedly evolving system capable of constant adaptation to oxygen and nutrient availability. The exact type of cancer metabolism arises from the combined effects of factors intrinsic to the cancer cells and factors proposed by the tumor microenvironment.
Martina Raudenska +3 more
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Atherosclerosis, Caveolae and Caveolin-1
2012Atherosclerosis is a disease of the blood vessel characterized by the development of an arterial occlusion containing lipid and cellular deposits. Caveolae are 50-100 nm cell surface plasma membrane invaginations that are believed to play an important role in the regulation of cellular signaling and transport of molecules among others. These organelles
Pavlides, Stephanos +4 more
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Caveolin‐1 expression in Schwann cells
Glia, 1999Caveolae are non-clathrin-coated invaginations of the plasma membrane, which are present in most cell types. An integral component of caveolae is the caveolin family of related proteins, which not only forms the structural framework of caveolae, but also likely subserves its functional roles, including regulation of signal transduction and cellular ...
Mikol, Daniel D. +3 more
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Retinal Caveolin-1 Modulates Neuroprotective Signaling
2015Caveolin-1 (Cav-1), the scaffolding protein of caveolae, is expressed in several retinal cell types and is associated with ocular pathologies. Cav-1 modulates neuroinflammatory/neuroprotective responses to central nervous system injury. We have shown that loss of Cav-1 results in a blunted cytokine response in retinas challenged with inflammatory ...
Reagan, A. +6 more
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Caveolin-1 Is Essential for Liver Regeneration
Science, 2006Liver regeneration is an orchestrated cellular response that coordinates cell activation, lipid metabolism, and cell division. We found that caveolin-1 gene–disrupted mice ( cav1 –/– mice) exhibited impaired liver regeneration and ...
Fernandez, Manuel A. +9 more
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2011
Increasing evidences in the last years suggested a possible involvement of caveolin-1 (cav-1) in the biology of brain tumors. In vitro studies on glioma cell lines as well as immuno-phenotyping of primary human gliomas reported that cav-1 expression in brain tumors varies according to the histotype and grade, and could bear prognostic significance in ...
SENETTA, REBECCA, CASSONI, Paola
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Increasing evidences in the last years suggested a possible involvement of caveolin-1 (cav-1) in the biology of brain tumors. In vitro studies on glioma cell lines as well as immuno-phenotyping of primary human gliomas reported that cav-1 expression in brain tumors varies according to the histotype and grade, and could bear prognostic significance in ...
SENETTA, REBECCA, CASSONI, Paola
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Caveolin-1 and Prostate Cancer Progression
2012Caveolin-1 was identified in the 1990s as a marker of aggressive prostate cancer. The caveolin-1 protein localizes to vesicular structures called caveolae and has been shown to bind and regulate many signaling proteins involved in oncogenesis. Caveolin-1 also has lipid binding properties and mediates aspects of cholesterol and fatty acid metabolism and
Michael R, Freeman +2 more
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Oxidative Stress, Caveolae and Caveolin-1
2004Oxidative stress underlies a range of pathophysiological conditions. Reactive oxygen species are also generated intracellularly to serve as second messengers and some are linked to caveolae/raft signalling systems. The effect of oxidative stress on caveolin-1 expression, post-translational modifications, membrane trafficking and function are described.
Parat, Marie-Odile, Fox, Paul L
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