Results 261 to 270 of about 60,250 (276)
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CAVEOLIN-1: Role in Cell Signaling
2012Caveolins (Cavs) are integrated plasma membrane proteins that are complex signaling regulators with numerous partners and whose activity is highly dependent on cellular context. Cavs are both positive and negative regulators of cell signaling in and/or out of caveolae, invaginated lipid raft domains whose formation is caveolin expression dependent ...
Cécile, Boscher, Ivan Robert, Nabi
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Isoforms of caveolin-1 and caveolar structure
Journal of Cell Science, 2000ABSTRACT The relationship between caveolin-1 isoforms (α and β) and caveolar ultrastructure was studied. By immunofluorescence microscopy of human fibroblasts, caveolae were observed as dots positive for caveolin-1, but many dots labeled by an antibody recognizing both isoforms (anti-αβ) were not labeled by another antibody specific for ...
T, Fujimoto, H, Kogo, R, Nomura, T, Une
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Caveolin-1 re-expression reverses G0/G1 arrest in caveolin-1 knockout mesangial cells
Wuhan University Journal of Natural Sciences, 2010Flow cytometry, BrdU incorporation, and western blotting were used to investigate whether caveolin-1 (Cav-1) is involved in cell cycle progression of renal glomerular mesangial cells. Wide type mesangial cells re-entered the cell cycle after 22 h incubation with 20% fetal bovine serum (FBS) and Cav-1 knockout cells remained in G0/G1 phase after 48 h ...
Tingting Wu +4 more
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Caveolin‐1 facilitates cyclooxygenase‐2 protein degradation
Journal of Cellular Biochemistry, 2009AbstractCyclooxygenase‐2 (COX‐2) plays major roles in diverse physiological and pathological processes such as inflammation and tumorigenesis. Transcriptional control of COX‐2 has been extensively investigated and characterized, but its post‐translational control is less clear. Here, we report a novel mechanism by which COX‐2 is degraded.
Shu-Fen, Chen +8 more
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Caveolin-1 stops profibrogenic signaling?
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2008caveolae are small, invaginated surface structures in the plasma membrane of fully differentiated cells such as endothelial cells, epithelial cells, adipocytes, and fibroblasts. The principal components of caveolae are proteins called caveolins, of which caveolin-1 (cav-1) is best characterized ...
Hong Pyo, Kim, Augustine M K, Choi
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Caveolae and caveolin-1 in reptilian liver
Micron, 2011Caveolae are plasma-membrane invaginations that, by interacting with membrane-associated molecules such as endothelial nitric oxide synthase and tyrosine kinases, precisely regulate cell-signalling pathways responsible for cell structure and cell function. Indeed, there is widespread evidence that caveolae associate, structurally and functionally, with
Joanna M, Biazik +2 more
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2011
Caveolin-1 (Cav-1), the main protein component of caveolae, is expressed in several differentiated cell types such as mammary epithelial cells. It is well-established that caveolae function as an organizing center that recruits and sequesters various signaling molecules.
Gloria Bonuccelli, Michael P. Lisanti
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Caveolin-1 (Cav-1), the main protein component of caveolae, is expressed in several differentiated cell types such as mammary epithelial cells. It is well-established that caveolae function as an organizing center that recruits and sequesters various signaling molecules.
Gloria Bonuccelli, Michael P. Lisanti
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Caveats of caveolin-1 in cancer progression
Cancer Letters, 2008Caveolin-1, an essential scaffold protein of caveolae and cellular transport processes, lately gained recognition as a stage- and tissue-specific tumor modulator in vivo. Patient studies and rodent models corroborated its janus-faced role as a tumor suppressor in non-neoplastic tissue, its down-regulation (loss of function) upon transformation and its ...
Elke, Burgermeister +4 more
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Medical Microbiology and Immunology, 2013
Caveolin-1 is one of the major constituents of caveolae. Both Cav-1 and PrP are plasma membrane proteins, which show active capacities for molecular interactions with many other proteins or agents, including themselves. Using yeast two-hybrid system and immunoprecipitation, we reconfirmed the molecular interaction between human Cav-1 and PrP.
Qi, Shi +11 more
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Caveolin-1 is one of the major constituents of caveolae. Both Cav-1 and PrP are plasma membrane proteins, which show active capacities for molecular interactions with many other proteins or agents, including themselves. Using yeast two-hybrid system and immunoprecipitation, we reconfirmed the molecular interaction between human Cav-1 and PrP.
Qi, Shi +11 more
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American Journal of Physiology-Cell Physiology, 2001
Numerous components of the cAMP-based signaling cascade, namely G-proteins and G- protein coupled receptors, adenylyl cyclase, and protein kinase A (PKA) have been localized to caveolae and shown to be regulated by the caveolar marker proteins, the caveolins.
B, Razani, M P, Lisanti
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Numerous components of the cAMP-based signaling cascade, namely G-proteins and G- protein coupled receptors, adenylyl cyclase, and protein kinase A (PKA) have been localized to caveolae and shown to be regulated by the caveolar marker proteins, the caveolins.
B, Razani, M P, Lisanti
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