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Caveolin-1 Is Essential for Liver Regeneration [PDF]
Science, 2006 Liver regeneration is an orchestrated cellular response that coordinates cell activation, lipid metabolism, and cell division. We found that caveolin-1 gene–disrupted mice ( cav1 –/– mice) exhibited impaired liver regeneration and low survival after a partial hepatectomy ...
Fernandez, Manuel A. +9 more
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Atherosclerosis, Caveolae and Caveolin-1
2012Atherosclerosis is a disease of the blood vessel characterized by the development of an arterial occlusion containing lipid and cellular deposits. Caveolae are 50-100 nm cell surface plasma membrane invaginations that are believed to play an important role in the regulation of cellular signaling and transport of molecules among others. These organelles
Pavlides, Stephanos +4 more
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Medical Microbiology and Immunology, 2013
Caveolin-1 is one of the major constituents of caveolae. Both Cav-1 and PrP are plasma membrane proteins, which show active capacities for molecular interactions with many other proteins or agents, including themselves. Using yeast two-hybrid system and immunoprecipitation, we reconfirmed the molecular interaction between human Cav-1 and PrP.
Han Sun +13 more
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Caveolin-1 is one of the major constituents of caveolae. Both Cav-1 and PrP are plasma membrane proteins, which show active capacities for molecular interactions with many other proteins or agents, including themselves. Using yeast two-hybrid system and immunoprecipitation, we reconfirmed the molecular interaction between human Cav-1 and PrP.
Han Sun +13 more
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2011
Increasing evidences in the last years suggested a possible involvement of caveolin-1 (cav-1) in the biology of brain tumors. In vitro studies on glioma cell lines as well as immuno-phenotyping of primary human gliomas reported that cav-1 expression in brain tumors varies according to the histotype and grade, and could bear prognostic significance in ...
SENETTA, REBECCA, CASSONI, Paola
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Increasing evidences in the last years suggested a possible involvement of caveolin-1 (cav-1) in the biology of brain tumors. In vitro studies on glioma cell lines as well as immuno-phenotyping of primary human gliomas reported that cav-1 expression in brain tumors varies according to the histotype and grade, and could bear prognostic significance in ...
SENETTA, REBECCA, CASSONI, Paola
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Caveolin‐1 expression in Schwann cells
Glia, 1999Caveolae are non-clathrin-coated invaginations of the plasma membrane, which are present in most cell types. An integral component of caveolae is the caveolin family of related proteins, which not only forms the structural framework of caveolae, but also likely subserves its functional roles, including regulation of signal transduction and cellular ...
Mikol, Daniel D. +3 more
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Caveolin‐1 in oncogenic metabolic symbiosis
International Journal of Cancer, 2020Metabolic phenotypes of cancer cells are heterogeneous and flexible as a tumor mass is a hurriedly evolving system capable of constant adaptation to oxygen and nutrient availability. The exact type of cancer metabolism arises from the combined effects of factors intrinsic to the cancer cells and factors proposed by the tumor microenvironment.
Michal Masarik +6 more
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Expression of Caveolin-1 and Caveolin-2 in the Human Pituitary: An Immunohistochemical Study
Endocrine Pathology, 2004Caveolins are coat proteins of caveolae, the plasmalemmal transport vesicles. To our knowledge their presence in the human pituitary and various types of hypophysial adenomas has not been investigated. In the present work, expression of caveolin-1 and caveolin-2 was studied by immunohistochemistry using the streptavidin-biotin-peroxidase complex method.
Fabio Rotondo +5 more
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Isoforms of caveolin-1 and caveolar structure
Journal of Cell Science, 2000ABSTRACT The relationship between caveolin-1 isoforms (α and β) and caveolar ultrastructure was studied. By immunofluorescence microscopy of human fibroblasts, caveolae were observed as dots positive for caveolin-1, but many dots labeled by an antibody recognizing both isoforms (anti-αβ) were not labeled by another antibody specific for ...
Tomoko Une +3 more
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Oxidative Stress, Caveolae and Caveolin-1
2004Oxidative stress underlies a range of pathophysiological conditions. Reactive oxygen species are also generated intracellularly to serve as second messengers and some are linked to caveolae/raft signalling systems. The effect of oxidative stress on caveolin-1 expression, post-translational modifications, membrane trafficking and function are described.
Parat, Marie-Odile, Fox, Paul L
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Caveats of caveolin-1 in cancer progression
Cancer Letters, 2008Caveolin-1, an essential scaffold protein of caveolae and cellular transport processes, lately gained recognition as a stage- and tissue-specific tumor modulator in vivo. Patient studies and rodent models corroborated its janus-faced role as a tumor suppressor in non-neoplastic tissue, its down-regulation (loss of function) upon transformation and its ...
Roland M. Schmid +4 more
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