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Caveolae and caveolin-1 in reptilian liver
Micron, 2011Caveolae are plasma-membrane invaginations that, by interacting with membrane-associated molecules such as endothelial nitric oxide synthase and tyrosine kinases, precisely regulate cell-signalling pathways responsible for cell structure and cell function. Indeed, there is widespread evidence that caveolae associate, structurally and functionally, with
Joanna M. Biazik +2 more
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Tyrosine Phosphorylation of Caveolin-1 in the Endothelium
Experimental Cell Research, 1999Caveolin-1, a scaffolding protein of caveolae, is known to be tyrosine-phosphorylated by Src kinases. Recently we generated a specific antibody to caveolin-1 phosphorylated at tyrosine-14 (PY14) (R. Nomura and T. Fujimoto, 1999, Mol. Biol. Cell 10, 975-986).
Takeo Aoki +2 more
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2011
Caveolin-1 (Cav-1), the main protein component of caveolae, is expressed in several differentiated cell types such as mammary epithelial cells. It is well-established that caveolae function as an organizing center that recruits and sequesters various signaling molecules.
Michael P. Lisanti, Gloria Bonuccelli
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Caveolin-1 (Cav-1), the main protein component of caveolae, is expressed in several differentiated cell types such as mammary epithelial cells. It is well-established that caveolae function as an organizing center that recruits and sequesters various signaling molecules.
Michael P. Lisanti, Gloria Bonuccelli
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The role of caveolin‐1 in cardiovascular regulation
Acta Physiologica, 2009AbstractCaveolae are omega‐shaped membrane invaginations present in essentially all cell types in the cardiovascular system, and numerous functions have been ascribed to these structures. Caveolae formation depends on caveolins, cholesterol and polymerase I and transcript release factor‐Cavin (PTRF‐Cavin).
Karl Swärd, Awahan Rahman
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The Role of Caveolin-1 in Retinal Inflammation
2019Although the retina resides within the immune-protected ocular environment, inflammatory processes mounted in the eye can lead to retinal damage. Unchecked chronic ocular inflammation leads to retinal damage. Thus, retinal degenerative diseases that result in chronic inflammation accelerate retinal tissue destruction and vision loss.
Jami M. Gurley, Michael H. Elliott
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American Journal of Physiology-Cell Physiology, 2001
Numerous components of the cAMP-based signaling cascade, namely G-proteins and G- protein coupled receptors, adenylyl cyclase, and protein kinase A (PKA) have been localized to caveolae and shown to be regulated by the caveolar marker proteins, the caveolins.
Babak Razani, Michael P. Lisanti
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Numerous components of the cAMP-based signaling cascade, namely G-proteins and G- protein coupled receptors, adenylyl cyclase, and protein kinase A (PKA) have been localized to caveolae and shown to be regulated by the caveolar marker proteins, the caveolins.
Babak Razani, Michael P. Lisanti
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The role of caveolin-1 in the regulation of angiogenesis
Italian journal of anatomy and embryology, 2012Caveolin-1 (cav-1) is the principal structural component of caveolae which functions as scaffolding protein for the integration of a variety of signaling pathways. In this study, we show that siRNA-induced cav-1 down regulation in human endothelial cells (EC) increased cell size and provoked cell cycle arrest at G1/S phase transition.
D'Alessio, Alessio, Sica, Gigliola
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Biochemical and Biophysical Research Communications, 2015
Although most smooth muscle neoplasms detected in the human uterus are benign, uterine leiomyosarcoma (Ut-LMS) is extremely malignant with high rates of recurrence and metastasis. CAVEOLIN 1 (CAV1) levels in the epithelial cells of some carcinomas have been reported to increase during tumor progression. We herein evaluated the relationship between CAV1
Tomoyuki Ichimura +4 more
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Although most smooth muscle neoplasms detected in the human uterus are benign, uterine leiomyosarcoma (Ut-LMS) is extremely malignant with high rates of recurrence and metastasis. CAVEOLIN 1 (CAV1) levels in the epithelial cells of some carcinomas have been reported to increase during tumor progression. We herein evaluated the relationship between CAV1
Tomoyuki Ichimura +4 more
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Caveolin-1 and Prostate Cancer Progression
2012Caveolin-1 was identified in the 1990s as a marker of aggressive prostate cancer. The caveolin-1 protein localizes to vesicular structures called caveolae and has been shown to bind and regulate many signaling proteins involved in oncogenesis. Caveolin-1 also has lipid binding properties and mediates aspects of cholesterol and fatty acid metabolism and
Michael R. Freeman +5 more
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CAVEOLIN-1: Role in Cell Signaling
2012Caveolins (Cavs) are integrated plasma membrane proteins that are complex signaling regulators with numerous partners and whose activity is highly dependent on cellular context. Cavs are both positive and negative regulators of cell signaling in and/or out of caveolae, invaginated lipid raft domains whose formation is caveolin expression dependent ...
Cecile Boscher, Ivan R. Nabi
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