Results 311 to 320 of about 24,232,284 (333)
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Caveolin-1 Is Essential for Liver Regeneration
Science, 2006Liver regeneration is an orchestrated cellular response that coordinates cell activation, lipid metabolism, and cell division. We found that caveolin-1 gene–disrupted mice ( cav1 –/– mice) exhibited impaired liver regeneration and ...
Fernandez, Manuel A. +9 more
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Caveolin-1 and Prostate Cancer Progression
2012Caveolin-1 was identified in the 1990s as a marker of aggressive prostate cancer. The caveolin-1 protein localizes to vesicular structures called caveolae and has been shown to bind and regulate many signaling proteins involved in oncogenesis. Caveolin-1 also has lipid binding properties and mediates aspects of cholesterol and fatty acid metabolism and
Michael R, Freeman +2 more
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Oxidative Stress, Caveolae and Caveolin-1
2004Oxidative stress underlies a range of pathophysiological conditions. Reactive oxygen species are also generated intracellularly to serve as second messengers and some are linked to caveolae/raft signalling systems. The effect of oxidative stress on caveolin-1 expression, post-translational modifications, membrane trafficking and function are described.
Parat, Marie-Odile, Fox, Paul L
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CAVEOLIN-1: Role in Cell Signaling
2012Caveolins (Cavs) are integrated plasma membrane proteins that are complex signaling regulators with numerous partners and whose activity is highly dependent on cellular context. Cavs are both positive and negative regulators of cell signaling in and/or out of caveolae, invaginated lipid raft domains whose formation is caveolin expression dependent ...
Cécile, Boscher, Ivan Robert, Nabi
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Isoforms of caveolin-1 and caveolar structure
Journal of Cell Science, 2000ABSTRACT The relationship between caveolin-1 isoforms (α and β) and caveolar ultrastructure was studied. By immunofluorescence microscopy of human fibroblasts, caveolae were observed as dots positive for caveolin-1, but many dots labeled by an antibody recognizing both isoforms (anti-αβ) were not labeled by another antibody specific for ...
T, Fujimoto, H, Kogo, R, Nomura, T, Une
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Caveolin-1 re-expression reverses G0/G1 arrest in caveolin-1 knockout mesangial cells
Wuhan University Journal of Natural Sciences, 2010Flow cytometry, BrdU incorporation, and western blotting were used to investigate whether caveolin-1 (Cav-1) is involved in cell cycle progression of renal glomerular mesangial cells. Wide type mesangial cells re-entered the cell cycle after 22 h incubation with 20% fetal bovine serum (FBS) and Cav-1 knockout cells remained in G0/G1 phase after 48 h ...
Tingting Wu +4 more
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Caveolin‐1 facilitates cyclooxygenase‐2 protein degradation
Journal of Cellular Biochemistry, 2009AbstractCyclooxygenase‐2 (COX‐2) plays major roles in diverse physiological and pathological processes such as inflammation and tumorigenesis. Transcriptional control of COX‐2 has been extensively investigated and characterized, but its post‐translational control is less clear. Here, we report a novel mechanism by which COX‐2 is degraded.
Shu-Fen, Chen +8 more
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Caveolin-1 stops profibrogenic signaling?
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2008caveolae are small, invaginated surface structures in the plasma membrane of fully differentiated cells such as endothelial cells, epithelial cells, adipocytes, and fibroblasts. The principal components of caveolae are proteins called caveolins, of which caveolin-1 (cav-1) is best characterized ...
Hong Pyo, Kim, Augustine M K, Choi
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Caveolae and caveolin-1 in reptilian liver
Micron, 2011Caveolae are plasma-membrane invaginations that, by interacting with membrane-associated molecules such as endothelial nitric oxide synthase and tyrosine kinases, precisely regulate cell-signalling pathways responsible for cell structure and cell function. Indeed, there is widespread evidence that caveolae associate, structurally and functionally, with
Joanna M, Biazik +2 more
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2011
Caveolin-1 (Cav-1), the main protein component of caveolae, is expressed in several differentiated cell types such as mammary epithelial cells. It is well-established that caveolae function as an organizing center that recruits and sequesters various signaling molecules.
Gloria Bonuccelli, Michael P. Lisanti
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Caveolin-1 (Cav-1), the main protein component of caveolae, is expressed in several differentiated cell types such as mammary epithelial cells. It is well-established that caveolae function as an organizing center that recruits and sequesters various signaling molecules.
Gloria Bonuccelli, Michael P. Lisanti
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