Results 61 to 70 of about 24,232,284 (333)

Caveolin-1 is involved in fatty infiltration and bone-tendon healing of rotator cuff tear

Molecular Medicine, 2023
Background Caveolin-1 has been predicted, based on RNA transcriptome sequencing, as a key gene in rotator cuff tear (RCT) and it is related to fatty infiltration.
Shanhong Fang, Mengqiang You, Jie Wei, Peng Chen   +3 more
doaj   +1 more source

Caveolin-1 mediates cellular distribution of HER2 and affects trastuzumab binding and therapeutic efficacy

Nature Communications, 2018
Human epidermal growth factor receptor 2 (HER2) gene amplification and/or protein overexpression in tumors is a prerequisite for initiation of trastuzumab therapy. Although HER2 is a cell membrane receptor, differential rates of endocytosis and recycling
Patricia M. R. Pereira, Sai Kiran Sharma, L. Carter, K. J. Edwards, J. Pourat, Ashwin Ragupathi, Y. Janjigian, J. Durack, Jason S. Lewis   +8 more
semanticscholar   +1 more source

Critical Role of Caveolin-1 Loss/Dysfunction in Pulmonary Hypertension

Medical Sciences, 2021
Pulmonary hypertension (PH) is a rare disease with a high morbidity and mortality rate. A number of systemic diseases and genetic mutations are known to lead to PH.
Rajamma Mathew
doaj   +1 more source

Caveolin-1-dependent and -independent membrane domains [PDF]

Journal of Lipid Research, 2009
Lipid rafts defined as cholesterol- and sphingomyelin-rich domains have been isolated from different cell types that vary greatly in their lipid profiles. Here, we investigated the contribution of the structural protein caveolin-1 (Cav1) to the overall lipid composition and domain abundance in mouse embryonic fibroblasts (MEFs) from wild-type (WT) or ...
Le Lay, Soazig, Li, Qiong, Proschogo, Nicholas, Rodriguez, Macarena, Gunaratnam, Krishanthi, Cartland, Siân, Rentero, Carles, Jessup, Wendy, Mitchell, Todd, Gaus, Katharina   +9 more
openaire   +5 more sources

Caveolin-1 regulates Rac1 activation and rat pulmonary microvascular endothelial hyperpermeability induced by TNF-α. [PDF]

PLoS ONE, 2013
A multiplicity of vital cellular and tissue level functions are controlled by caveolin-1 and it is considered to be an important candidate for targeted therapeutics.
Min Shao, Yang Yue, Geng-Yun Sun, Qing-Hai You, Nan Wang, Dan Zhang   +5 more
doaj   +1 more source

Canine respiratory coronavirus employs caveolin-1-mediated pathway for internalization to HRT-18G cells [PDF]

, 2018
Canine respiratory coronavirus (CRCoV), identified in 2003, is a member of the Coronaviridae family. The virus is a betacoronavirus and a close relative of human coronavirus OC43 and bovine coronavirus.
A Milewska, A Pratelli, A Quan, Aleksandra Milewska, AM Zaki, Artur Szczepanski, B Hernaez, B Jancekova, BA Mainou, BJ Dille, C Burkard, C Kooi, C Liu, C Liu, D Dutta, DM Blau, E Dietzel, E Girard, E Hamme Van, EJ Bowman, F Samson, G Preta, GA Wudiri, GM Li, GR Ares, H Imhoff, H Lin, H Wang, IC Huang, IM Mackay, J Li, J Schindelin, J Somsel Rodman, JA Mitchell, JK Millet, JL Wang, JP Lim, JR Henley, Judy A. Mitchell, K Erles, K Erles, K Owczarek, K Shirato, K Shirato, Katarzyna Owczarek, Krzysztof Pyrc, KS Choi, L Kleist von, L Pelkmans, LH Wang, LJ Reed, M Marsh, MG Hemida, MJ Geisow, MJ Vincent, O Achour, O Heikkila, P Duckert, P Eifart, P Oh, Q Xu, R Nomura, S Bertram, S Bolte, S Gierer, S Matsuyama, SL Priestnall, TA Hill, VC Chu, X Ren, Y Inoue, Y Phonphok, Z Qian, Z Qinfen, Zbigniew Baster, Zenon Rajfur   +75 more
core   +8 more sources

Hepatitis B virus X protein suppresses caveolin-1 expression in hepatocellular carcinoma by regulating DNA methylation

BMC Cancer, 2012
Background To understand the molecular mechanisms of caveolin-1 downregulation by hepatitis B virus X protein (HBx). Methods The DNA methylation status of the caveolin-1 promoter was examined by nested methylation-specific PCR of 33 hepatitis B virus ...
Yan Jun, Lu Qian, Dong Jiahong, Li Xiaowu, Ma Kuansheng, Cai Lei   +5 more
doaj   +1 more source

Reciprocal regulation of eNOS and caveolin-1 functions in endothelial cells

Molecular Biology of the Cell, 2018
We hypothesized that the maintenance of vascular homeostasis is critically dependent on the expression and reciprocal regulation of caveolin-1 (Cav-1) and endothelial nitric oxide synthase (eNOS) in endothelial cells (ECs).
Zhenlong Chen, Suellen D. S. Oliveira, Adriana M. Zimnicka, Ying Jiang, T. Sharma, Stone Chen, Orly Lazarov, M. Bonini, J. Haus, R. Minshall   +9 more
semanticscholar   +1 more source

Caveolin-1 expression in hyperproliferative skin disorders: A potential predictive marker of disease severity and progression

Dermatologica Sinica, 2018
Background: Caveolin-1 (CAV-1) is a key structural and functional membrane protein that is thought to play a role in controlling cellular proliferation and differentiation. Objective: To study the immunohistochemical expression of caveolin-1 in psoriasis
Shereen Farouk Gheida, Yomna Mazid El-Hamd Neinaa, Dareen Abd El-Aziz Mohammed   +2 more
doaj   +1 more source

Caveolin-1 Knockdown Decreases SMMC7721 Human Hepatocellular Carcinoma Cell Invasiveness by Inhibiting Vascular Endothelial Growth Factor-Induced Angiogenesis

Canadian Journal of Gastroenterology and Hepatology, 2020
Background. Recently, several studies have demonstrated that caveolin-1 overexpression is involved in apoptosis resistance, angiogenesis, and invasiveness in hepatocellular carcinoma (HCC).
Zhi-Bo Zhang, Zheng Shi, Lan-Fang Yang, Hong-Bin Gao   +3 more
doaj   +1 more source