Results 71 to 80 of about 35,385 (262)

Cellular apoptosis is associated with increased caveolin-1 expression in macrophages

Journal of Lipid Research, 2003
Macrophage apoptosis is an important factor in determining the efficiency of the immune response, atherosclerotic lesion stability, and clearance of aged cells by phagocytosis.
Peter Gargalovic, Ladislav Dory
doaj   +1 more source

Expression of Caveolin-1 Is Required for the Transport of Caveolin-2 to the Plasma Membrane [PDF]

Journal of Biological Chemistry, 1999
Caveolins-1 and -2 are normally co-expressed, and they form a hetero-oligomeric complex in many cell types. These caveolin hetero-oligomers are thought to represent the assembly units that drive caveolae formation in vivo. However, the functional significance of the interaction between caveolins-1 and -2 remains unknown.
Cesare Peschle, Cesare Peschle, Ferruccio Galbiati, Tsuneya Ikezu, Jeffrey A. Engelman, Isabella Parolini, Isabella Parolini, Philipp E. Scherer, Francesco Grignani, Michael P. Lisanti, Massimo Sargiacomo, Rosalia Mora, Giovanni Rizzo, Enrique Rodriguez-Boulan, Takashi Okamoto   +14 more
openaire   +4 more sources

Nanoinjection Platform for Drug Delivery in Breast Cancer Therapeutics

Advanced Materials Interfaces, EarlyView.
A schematic shows Nanoarchaeosomes loaded with doxorubicin (NAD) delivered via silicon nanotubes (SiNTs) into MCF‐7 cells, triggering apoptosis and necrosis. Released doxorubicin generates ROS, disrupts mitochondria, and intercalates DNA. This dual‐action nanoinjection enhances cytotoxicity and improves breast cancer therapy efficacy.
Kaviya Vijayalakshmi Babunagappan, Subastri Ariraman, Jann Harberts, Vimalraj Selvaraj, Mukilarasi Bedatham, Narendran Sekar, Nicolas H Voelcker, Roey Elnathan, Swathi Sudhakar   +8 more
wiley   +1 more source

Caveolin-1 in Cell Migration and Metastasis

Current Molecular Medicine, 2014
Caveolin-1 is a member of the caveolin family that has been ascribed a dual role in cancer. In early stages of disease the protein functions predominantly as a tumor suppressor, whereas at later stages, caveolin-1 expression is associated with tumor progression and metastasis. Here, some mechanisms associated with caveolin-1-dependent tumor suppression
Nunez-Wehinger, S., Ortiz, R. J., Diaz, N., Diaz, J., Lobos-Gonzalez, L., Quest, A. F. G.   +5 more
openaire   +5 more sources

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Advanced Therapeutics, EarlyView.
This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar, Weiwei Guo, Xin Shen, Yimeng Fang, Yilin Liu, Peng‐Yuan Wang, Roey Elnathan, Yaping Chen   +7 more
wiley   +1 more source

Differential expression of Caveolin-1 in hepatocellular carcinoma: correlation with differentiation state, motility and invasion

BMC Cancer, 2009
Background Caveolin-1 is the main component of caveolae membrane structures and has different roles during tumorigenesis in different cancer types with varying expression profiles, indicating that the role of caveolin-1 varies according to tumor type. In
Kilic Murat, Sagol Ozgul, Yilmaz Funda, Nart Deniz, Erdal Esra, Cokakli Murat, Karademir Sedat, Atabey Nese   +7 more
doaj   +1 more source

Co-regulation of cell polarization and migration by caveolar proteins PTRF/Cavin-1 and caveolin-1. [PDF]

PLoS ONE, 2012
Caveolin-1 and caveolae are differentially polarized in migrating cells in various models, and caveolin-1 expression has been shown to quantitatively modulate cell migration.
Michelle M Hill, Noor Huda Daud, Cho Sanda Aung, Dorothy Loo, Sally Martin, Samantha Murphy, Debra M Black, Rachael Barry, Fiona Simpson, Libin Liu, Paul F Pilch, John F Hancock, Marie-Odile Parat, Robert G Parton   +13 more
doaj   +1 more source

Caveolin-1, caveolin-3 and VEGF expression in the masticatory muscles of mdx mice

Folia Histochemica et Cytobiologica, 2011
Duchenne muscular dystrophy (DMD) and murine X-linked muscular dystrophy (mdx), its murine model, are characterized by muscle damage and muscle weakness associated with inflammation and new vessel formation. Caveolins, dystrophin-associated proteins, are involved in the pathogenesis of DMD, because increased numbers of caveolae are found in DMD and mdx
Tomasz Gedrange, Sven Morgenstern, Tomasz Gredes, Silke Lucke, Agnieszka Mielczarek, Alexander Spassov, Katarzyna Sporniak-Tutak, Christiane Kunert-Keil   +7 more
openaire   +4 more sources

Unraveling the Role of MDK‐SDC4 Interaction in Pancreatic Cancer‐Associated New‐Onset Diabetes by Single‐Cell Transcriptomic Analysis

Advanced Science, EarlyView.
Midkine (MDK) is a mediator of the interaction between pancreatic cancer and beta cells. MDK, which originated from pancreatic ductal adenocarcinoma cells, exerted deleterious effects on paraneoplastic beta cells by binding to the SDC4 receptor on the beta cell surface and subsequently downregulating the Ras signaling pathway, thereby impairing insulin
Zengyu Feng, Jianyao Lou, Chuanshuai Lin, Haocheng Yu, Yuheng Tu, Jiali Gong, Xiawei Li, Yulian Wu   +7 more
wiley   +1 more source

The TGF-β1/p53/PAI-1 Signaling Axis in Vascular Senescence: Role of Caveolin-1

Biomolecules, 2019
Stress-induced premature cellular senescence is a significant factor in the onset of age-dependent disease in the cardiovascular system. Plasminogen activator inhibitor-1 (PAI-1), a major TGF-β1/p53 target gene and negative regulator of the plasmin ...
Rohan Samarakoon, Stephen P. Higgins, Craig E. Higgins, Paul J. Higgins   +3 more
doaj   +1 more source