Results 141 to 150 of about 2,142 (162)

MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes [PDF]

Journal of Cell Biology, 2009
Polymerase I and transcript release factor (PTRF)/Cavin is a cytoplasmic protein whose expression is obligatory for caveola formation. Using biochemistry and fluorescence resonance energy transfer-based approaches, we now show that a family of related ...
Michele Bastiani, Libin Liu, Michelle M Hill   +2 more
exaly   +8 more sources

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Cavin‐2 in oral cancer: A potential predictor for tumor progression

Molecular Carcinogenesis, 2015
Cavin‐2 (CVN2) affects formation of large caveolae, which are membrane‐rich cholesterol domains associated with several functions in signal transduction. Accumulating evidence suggests that CVN2 is present in many cellular types; however, the molecular mechanisms of CVN2 in cancers and its clinical relevance are unknown.
Motoharu, Unozawa, Atsushi, Kasamatsu, Morihiro, Higo, Chonji, Fukumoto, Tomoyoshi, Koyama, Tomomi, Sakazume, Dai, Nakashima, Katsunori, Ogawara, Hidetaka, Yokoe, Masashi, Shiiba, Hideki, Tanzawa, Katsuhiro, Uzawa   +11 more
openaire   +2 more sources

Cavin-2 is a specific marker for detection of well-differentiated liposarcoma

Biochemical and Biophysical Research Communications, 2017
Caveolae are cholesterol enriched invaginations of the plasma membrane involved in a variety of processes, including glucose and fatty acids absorption, cell transduction and mechanoprotection. The biogenesis and function of caveolae depend on the activity of Caveolin (Cav-1, -2 and -3) and Cavin (Cavin-1, -2, -3 and -4) protein families.
CODENOTTI, SILVIA, VEZZOLI, Marika, POLIANI, Pietro Luigi, COMINELLI, Manuela, MONTI, Eugenio, FANZANI, Alessandro   +5 more
openaire   +4 more sources

Abstract 301: Cavin-2 Deletion Attenuates Fibroblast Activation and Cardiac Fibrosis via TGF-β Signaling by Interacting With Hsp90

Circulation Research, 2020
Introduction: Heart failure (HF) is a progressive disease associated with high morbidity and mortality. A major cause of HF is the adverse tissue remodeling with interstitial fibrosis. Excessive extracellular matrix (ECM) accumulation is involved in the poor outcome.
Yusuke Higuchi, Takehiro Ogata, Naohiko Nakanishi, Akira Sakamoto, Yumika Tsuji, Shinya Tomita, Satoaki Matoba   +6 more
openaire   +1 more source

Abstract 520: Cavin-2/SDPR in Cardiac Fibroblasts Modulates TGF-β/Smad Signaling and Promotes Pressure Overload-induced Fibrosis

Circulation Research, 2019
Introduction: Heart failure (HF) is a debilitating disease associated with high morbidity and mortality. The high mortality rate reflects the inadequacy of modern therapy and calls for new treatments. A major cause of HF is the adverse tissue remodeling with fibrosis. Excessive extracellular matrix (ECM) turnover is involved in
Yusuke Higuchi, Takehiro Ogata, Naohiko Nakanishi, Masahiro Nishi, Akira Sakamoto, Yumika Tsuji, Satoaki Matoba   +6 more
openaire   +1 more source

P151 L’hypoxie inhibe l’expression de Cavin1/PTRF et Cavin-2/SDPR et induit la disparition des cavéoles dans les adipocytes

Diabetes & Metabolism, 2014
Introduction Lors de l’obesite le developpement de zones d’hypoxie dans le tissu adipeux est implique dans le developpement de la resistance a l’insuline en inhibant la voie de signalisation de l’insuline dans les adipocytes. L’activation du recepteur de l’insuline depend de sa localisation dans les caveoles, dont la formation et la fonction sont ...
C. Regazzetti, K. Dumas, S. Lacas-Gervais, P. Peraldi, I. Dugail, S. Le Lay, Y. Le Marchand-Brustel, J. Tanti, M. Cormont, S. Giorgetti-Peraldi   +9 more
openaire   +1 more source

Cavin-2/SDPR in cardiac fibroblasts regulates cardiac fibrosis and function via TGF-β/Smad signaling in pressure-overloaded hearts

Journal of Molecular and Cellular Cardiology, 2020
Yusuke Higuchi, Takehiro Ogata, Masahiro Nishi, Naohiko Nakanishi, Akira Sakamoto, Yumika Tsuji, Satoaki Matoba   +6 more
openaire   +1 more source

Cavin-1 promotes M2 macrophages/microglia polarization via SOCS3

Inflammation Research, 2022
Fan Xu
exaly  

Physiological and pathological ventricular hypertrophy: a role for cavin-2 mediated Akt regulation

Cardiovascular Research
Raffaele Coppini, Lucrezia Giammarino, Elisabetta Cerbai   +2 more
openaire   +2 more sources

PTRF-Cavin, a Conserved Cytoplasmic Protein Required for Caveola Formation and Function

Cell, 2008
Michelle M Hill, Michele Bastiani, Matthew Kirkham   +2 more
exaly