Results 131 to 140 of about 71,388 (222)

Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment

MedComm, Volume 7, Issue 4, April 2026.
Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai, Chongxiang Wang, Ping Jiang, Xiaopeng Mei   +3 more
wiley   +1 more source

Epilepsy: Molecular Pathogenesis and Emerging Therapies

MedComm, Volume 7, Issue 4, April 2026.
Progress has been made in the molecular pathogenesis of epilepsy, revealing multiple therapeutic targets. Recent advances in pharmacology, materials science, and surgical technique, coupled with progress in targeted therapy and disruptive epilepsy network technology, have led to the emergence of innovative strategies for epilepsy treatment.
Wanbin Huang, Jiabin Zong, Yu Zhang, Ming Li, Songqing Pan, Zheman Xiao   +5 more
wiley   +1 more source

Species delimitation among Primula hirsuta and related taxa (Primulaceae) confirms the existence of cryptic species in the Europeans Alps

TAXON, Volume 75, Issue 2, April 2026.
Abstract Primula sect. Auricula is the largest plant clade endemic to Western European mountains and hence an important model to study speciation in mountain plants. Within this section, a clade of closely related and largely cryptic taxa, with P. hirsuta and P. pedemontana as its most prominent members, has remained taxonomically challenging. New taxa
Florian C. Boucher, Camille Voisin, Loïse Livache, Delphine Rioux, Cédric Dentant   +4 more
wiley   +1 more source

mGluR5, CB1 and neuroprotection

Oncotarget, 2016
Carvalho, Toniana G., Doria, Juliana G., Ribeiro, Fabiola M.   +2 more
openaire   +2 more sources

The Effects of Palmitoylethanolamide or Ibuprofen on the Abundance Profile and Synthesis Rate of Proteins in C2C12 Skeletal Myotubes

FASEB BioAdvances, Volume 8, Issue 4, April 2026.
(a) C2C12 myoblasts were cultured and differentiated over 7 days until mature myotubes were formed. (b) Myotubes were treated with PEA (10 μM), IBU (100 μM) or VC for 36 h. Simultaneously, cells were incubated with D2O (deuterium oxide) for isotopic labeling.
Paige L. Cole, Connor A. Stead, Jatin G. Burniston, Daniel J. Owens   +3 more
wiley   +1 more source

Associations of Low‐Level Prenatal Alcohol and Cannabis Exposure With Adolescent Cognitive Trajectories

Alcohol, Clinical and Experimental Research, Volume 50, Issue 4, April 2026.
Little evidence emerged for negative effects of low level prenatal alcohol, cannabis, or combined exposure on adolescents' cognitive development after accounting for sociodemographic factors. Families with social features positively associated with cognitive ability (e.g., education) may engage in low level drinking during pregnancy with few negative ...
Katie J. Paige, Nolan E. Ramer, Emma K. Devine, Omid Kardan, Louise Mewton, Lindsay M. Squeglia, Mary M. Heitzeg, Alexander S. Weigard   +7 more
wiley   +1 more source

Hardware Accelerators for Cardiovascular Signal Processing: A System-on-Chip Perspective

Micromachines
This study presents a comprehensive systematic analysis, investigating hardware accelerators specifically designed for real-time cardiovascular signal processing, focusing mainly on Electrocardiogram (ECG), Photoplethysmogram (PPG), and blood pressure ...
Rami Hariri, Marcian Cirstea, Mahdi Maktab Dar Oghaz, Khaled Benkrid, Oliver Faust   +4 more
doaj   +1 more source

Development of a novel risk score reflecting the relative harm potential of synthetic cannabinoids based on prevalence estimates, well‐documented intoxication cases and basic pharmacological data

Addiction, Volume 121, Issue 4, Page 870-882, April 2026.
Abstract Background and aims While the health hazards of synthetic cannabinoid receptor agonists (SCRAs) are often approximated using in vitro pharmacological parameters as surrogate, this approach fails to consider pharmacokinetic and pharmacodynamic complexity.
Michaela J. Sommer, Katharina Elisabeth Grafinger, Maren Hermanns‐Clausen, Volker Auwärter   +3 more
wiley   +1 more source

Signal Amplification in the HPT Axis—Evidence for Its Existence, Location, Significance, and Molecular Mechanisms

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Thyroid hormones (THs) are under negative feedback regulation via the hypothalamic–pituitary‐thyroid (HPT) axis. How this axis operates to keep the circulating THs within a narrow physiological range is not well understood quantitatively. Led by the design principle of robust homeostatic feedback control, here we review and synthesize the ...
Li Jing, Sarahna A. Moyd, Qiang Zhang
wiley   +1 more source

Sex‐specific impact of repeated adolescent vapour exposure to JWH‐018 on dopamine response, behaviour and pharmacokinetics across adolescence and adulthood

British Journal of Pharmacology, Volume 183, Issue 7, Page 1517-1538, April 2026.
Abstract Background and Purpose Alarming trends show that vaping e‐cigarettes containing synthetic cannabinoid receptor agonists, such as JWH‐018, is increasing among youth. However, the effects of these trends are unclear in both sexes. We therefore characterized the neuropharmacological effects of adolescent JWH‐018 inhalation in male and female rats.
Nicholas Pintori, Cristina Manis, Enrica Spano, Nicola Simola, Alessandro Ieraci, Pierluigi Caboni, Gaetano Di Chiara, Maria Antonietta De Luca   +7 more
wiley   +1 more source