Results 121 to 130 of about 71,388 (222)
Exploring the Ligand Efficacy of Cannabinoid Receptor 1 (CB1) using Molecular Dynamics Simulations
Scientific Reports, 2018 Cannabinoid receptor 1 (CB1) is a promising therapeutic target for a variety of disorders. Distinct efficacy profiles showed different therapeutic effects on CB1 dependent on three classes of ligands: agonists, antagonists, and inverse agonists.
Sang Won Jung, Art E. Cho, Wookyung Yu
doaj +1 more source
Circuit‐Selective FAAH Inhibition Suppresses Experimental Absence Seizures
CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.Selective inhibition of FAAH with PF‐04457845 enhances endogenous AEA signaling and suppresses absence seizures in Genetic Absence Epilepsy Rats from Strasbourg (GAERS). Video‐EEG recordings demonstrate a marked reduction in SWDs following both acute and subchronic FAAH inhibitions.
Tatiana P. Morais +3 more
wiley +1 more source
Fatty acid metabolism—an emerging regulatory node in T‐cell immunometabolism
Clinical &Translational Immunology, Volume 15, Issue 4, 2026.Abstract While the roles of glucose metabolism and tricarboxylic acid (TCA) cycle intermediates in immune regulation are well established, the contribution of fatty acid metabolism remains less well defined. In this review, we examine current knowledge on the immunomodulatory functions of fatty acid metabolism, with a particular focus on T‐cell biology.
Brett Chapel Arenberg +2 more
wiley +1 more source
DEN Open, Volume 6, Issue 1, April 2026.ABSTRACT Self‐expanding metallic stents (SEMSs) are an established palliative option for malignant colonic obstruction, including in cases with proximal lesions. However, SEMS placement across the ileocecal valve (ICV) can be technically challenging because of the anatomical curvature and luminal stenosis. Herein, we report a successful case of colonic
Takato Maeda +7 more
wiley +1 more source
New Insights into Cannabis Consumption; Abuses and Possible Therapeutic Effects [PDF]
, 2015 Cannabis is one of the oldest psychotropic drugs known to humanity. The paper assesses the current knowledge on the cannabis, including the mechanisms of action and the therapeutic potential of cannabinoids.
Baconi, Daniela Luiza +2 more
core +3 more sources
DEN Open, Volume 6, Issue 1, April 2026.ABSTRACT Endoscopic retrograde cholangiopancreatography (ERCP) is the standard procedure for biliary drainage; however, access can be challenging in patients with altered anatomy or tumor‐related distortion. Endoscopic ultrasound‐guided biliary drainage (EUS‐BD) is a common alternative, yet it is not always feasible, particularly in patients with prior
Akinobu Koiwai +7 more
wiley +1 more source
Food Science &Nutrition, Volume 14, Issue 4, April 2026.Graphical representation of the metabolic pathways modulated by saffron within defined microbial communities. In the tryptophan pathway, saffron decreased levels of tryptophan and anthranilic acid while increasing concentrations of indole‐3‐acetic acid and tryptamine.
Adelaide E. Horvath +9 more
wiley +1 more source
General Psychiatry, Volume 39, Issue 2, April 2026.ABSTRACT Background Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by pronounced heterogeneity in brain structure, which limits the development of targeted interventions. Morphological brain networks (MBNs) enable the mapping of coordinated structural features across brain regions at the individual level.
Huashuang Zhang +7 more
wiley +1 more source
Holocene sea‐level and environmental changes on the Isle of Mull, Scotland
Journal of Quaternary Science, Volume 41, Issue 3, Page 400-418, April 2026.ABSTRACT Sea‐level and coastal changes are reconstructed on the Isle of Mull, western Scotland, from 10 988 to 10 507 cal BP to the present. This research has produced the first SLIP for the Isle of Mull. A multiproxy approach including pollen, spore, foraminifera and diatom analyses reveals palaeoenvironmental changes from two coastal sites.
Katherine A. Selby +6 more
wiley +1 more source