Results 101 to 110 of about 40,137 (231)
Interação entre os sistemas endocanabinóide e glicocorticóide na extinção do condicionamento aversivo contextual em ratos [PDF]
, 2012 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em FarmacologiaA regulação das respostas emocionais é essencial para a saúde mental e a forma mais simples de regulação destas respostas é
Bitencourt, Rafael Mariano de
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Neurobiology of Disease, 2005 We have observed that systemic administration of cannabinoid CB1 antagonists exerts antiparkinsonian effects in rats with very severe nigral lesion (>95% cell loss), but not in rats with less severe lesion (85–95% cell loss).
Emilio Fernandez-Espejo +6 more
doaj +1 more source
Postcranial anatomy of the Miocene hippopotamoids of Toros‐Menalla, Chad
Journal of Anatomy, Volume 249, Issue 4, Page 924-949, October 2026.We establish a framework for the identification of postcranial remains in hippopotamoids by describing and comparing for the first time two late Miocene hippopotamoids from Toros‐Menalla, Chad (Hexaprotodon garyam, an early hippopotamid, and Libycosaurus bahri, the last African anthracothere) with the common hippopotamus.
Lorenzo Scribano +4 more
wiley +1 more source
Efeito anti-hiperalgésico e antiinflamatório de triterpenos pentacíclicos em modelos experimentais de hiperalgesia crônica: participação do sistema canabinóide [PDF]
, 2012 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2011O presente estudo revela que o tratamento oral com os triterpenos pentacíclicos betulina (30 mg/mg ...
Silva, Kathryn Ana Bortolini Simão da
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The Endocannabinoid System Differentially Regulates Escape Behavior in Mice
Frontiers in Behavioral Neuroscience, 2017 Among the hardwired behaviors, fear or survival responses certainly belong to the most evolutionary conserved ones. However, higher animals possess the ability to adapt to certain environments (e.g., novel foraging grounds), and, therefore, those ...
Andreas J. Genewsky, Carsten T. Wotjak
doaj +1 more source
Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.Physiological and Pathological Alterations in PV+ Neurons: Under physiological conditions, PV+ interneurons exhibit fast‐spiking properties and generate gamma oscillations at the cost of high energy consumption. In AD, PV+ neurons display abnormalities in ion channels, dendrites, neurotransmission, energy metabolism, and neural oscillations, ultimately
Mengyan Wu +5 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.Following CNS injury, NG2‐glia display distinct functional phases. In the early stage, NG2‐glia are rapidly activated, proliferate, migrate to the lesion site and secrete CSPGs, which form a chemical and physical barrier that inhibits axonal regeneration.
Yunyun Cai +4 more
wiley +1 more source
A Kannabinoid Receptor 1 (CB1) szerepének vizsgálata in vitro porcképződés során
, 2017 Az ízületi porcregeneráció elősegítése a mai napig nem megoldott feladat. Az elmúlt évek során felvetődött, hogy a kannabisz tartalmú készítmények alkalmazása különböző reumatoid- vagy oszteoarthritiszes megbetegedések során nemcsak fájdalomcsillapító és
Fürstál, Barbara
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Fenofibrate Recognition and Gq Protein Coupling Mechanisms of the Human Cannabinoid Receptor CB1
Advanced ScienceThe G‐protein‐coupled human cannabinoid receptor 1 (CB1) is a promising therapeutic target for pain management, inflammation, obesity, and substance abuse disorders.
Tianxin Wang +12 more
doaj +1 more source
Cannabinoid‐Inspired Fluorescent Boroisoquinolines for CB1 Receptor Imaging
ChemPhotoChem, Volume 10, Issue 9, September 2026.A cannabinoid‐inspired fluorescent boroisoquinoline, a low‐micromolar partial agonist of the human CB1 receptor, enabled imaging of CB1 receptors by confocal microscopy in live cells. The intrinsic fluorescence of our probe provides a unique opportunity for CB1 imaging while keeping receptor structure and pharmacology similar to that observed with ...
Dénes Szepesi Kovács +9 more
wiley +1 more source