Results 91 to 100 of about 71,388 (222)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Statistical networks emerging from link-node interactions

, 2005
We study a model for a statistical network formed by interactions between its nodes and links. Each node can be in one of two states (Ising spin up or down) and the node-link interaction facilitates linking between the like nodes.
Allahverdyan, A. E., Petrosyan, K. G.
core   +1 more source

Tonic endocannabinoid-mediated modulation of GABA release is independent of the CB1 content of axon terminals [PDF]

, 2015
The release of GABA from cholecystokinin-containing interneurons is modulated by type-1 cannabinoid receptors (CB1). Here we tested the hypothesis that the strength of CB1-mediated modulation of GABA release is related to the CB1 content of axon ...
Holderith, Noemi, Hájos, Norbert, Kirizs, Tekla, Lenkey, Nora, Máté, Zoltán, Nusser, Zoltan, Szabó, Gábor, Vizy, E. Sylvester   +7 more
core   +1 more source

Stress regulates endocannabinoid-CB1 receptor signaling [PDF]

Seminars in Immunology, 2014
The CB1 cannabinoid receptor is a G protein coupled receptor that is widely expressed throughout the brain. The endogenous ligands for the CB1 receptor (endocannabinoids) are N-arachidonylethanolamine and 2-arachidonoylglycerol; together the endocannabinoids and CB1R subserve activity dependent, retrograde inhibition of neurotransmitter release in the ...
openaire   +2 more sources

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Cannabinoid CB1 receptor activation mediates the opposing effects of amphetamine on impulsive action and impulsive choice.

PLoS ONE, 2011
It is well known that acute challenges with psychostimulants such as amphetamine affect impulsive behavior. We here studied the pharmacology underlying the effects of amphetamine in two rat models of impulsivity, the 5-choice serial reaction time task (5-
Joost Wiskerke, Nicky Stoop, Dustin Schetters, Anton N M Schoffelmeer, Tommy Pattij   +4 more
doaj   +1 more source

Metabolic Profiling of CB1 Neutral Antagonists [PDF]

, 2017
PIMSR is among the first neutral antagonists for the CB1R and was demonstrated pharmacologically to bind to the CB1R, yet not alter calcium flux. It was further shown computationally to be able to stabilize both the active and inactive states of CB1R revealing the molecular interactions that mechanistically afford the property of neutral antagonism ...
Herbert H, Seltzman, Rangan, Maitra, Katharine, Bortoff, Jay, Henson, Patricia H, Reggio, Daniel, Wesley, Joseph, Tam   +6 more
openaire   +2 more sources

Cannabidiol and cannabigerol ameliorate steatotic liver disease via phosphocreatine buffering and lysosomal restoration

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) and cannabigerol (CBG) alleviate hepatic steatosis in obese mice by shifting energy buffering towards phosphocreatine and enhancing lysosomal lipid degradation and trafficking. These effects are associated with increased creatine kinase activity and lysobisphosphatidic acid (LBPA) levels, highlighting a previously unrecognised ...
Radka Kočvarová, Shahar Azar, Bella Agranovich, Ifat Abramovich, Saveliy Kirillov, Alina Nemirovski, Saja Baraghithy, Inbar Plaschkes, Emmanuelle Merquiol, Alexander Rouvinski, Galia Blum, Liad Hinden, Joseph Tam   +12 more
wiley   +1 more source

Contribution of Altered Endocannabinoid System to Overactive mTORC1 Signaling in Focal Cortical Dysplasia

Frontiers in Pharmacology, 2019
Alterations of the PI3K/Akt/mammalian target of rapamycin complex 1 (mTORC1) signaling pathway are causally involved in a subset of malformations of cortical development (MCDs) ranging from focal cortical dysplasia (FCD) to hemimegalencephaly and ...
Daniel García-Rincón, Daniel García-Rincón, Javier Díaz-Alonso, Javier Díaz-Alonso, Juan Paraíso-Luna, Juan Paraíso-Luna, Zaira Ortega, Zaira Ortega, José Aguareles, José Aguareles, Adán de Salas-Quiroga, Adán de Salas-Quiroga, Cristina Jou, Inmaculada de Prada, Verónica Martínez-Cerdeño, Eleonora Aronica, Eleonora Aronica, Manuel Guzmán, Manuel Guzmán, María Ángeles Pérez-Jiménez, Ismael Galve-Roperh, Ismael Galve-Roperh   +21 more
doaj   +1 more source

The tree‐parasitic fungus Cryphonectria carpinicola discovered on European chestnut and European hornbeam in Azerbaijan

EPPO Bulletin, EarlyView.
Abstract The ascomycetous fungus Cryphonectria carpinicola is typically found in its asexual form on the European hornbeam, and its sexual state has only recently been discovered in deadwood of different Carpinus species in Japan. Recently, this fungus has been added to the EPPO Alert List due to its increasing incidence in the EPPO region and a ...
Carolina Cornejo, Dilzara Aghayeva, Ludwig Beenken   +2 more
wiley   +1 more source