Results 91 to 100 of about 36,753 (242)
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose New synthetic cannabinoid receptor agonists (SCRAs) are associated with severe adverse effects, including unexpected psychiatric symptoms. These compounds are mainly active through their potent agonism on the cannabinoid receptors CB1 and CB2.
Giorgia Corli +8 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Obesity involves profound disruptions in neuronal circuits, neuroendocrine communication and the endocannabinoid system. While global blockade of cannabinoid CB1 receptors improves metabolism, its clinical use is limited by neuropsychiatric side effects.
Oriane Onimus +7 more
wiley +1 more source
A Kannabinoid Receptor 1 (CB1) szerepének vizsgálata in vitro porcképződés során
, 2017 Az ízületi porcregeneráció elősegítése a mai napig nem megoldott feladat. Az elmúlt évek során felvetődött, hogy a kannabisz tartalmú készítmények alkalmazása különböző reumatoid- vagy oszteoarthritiszes megbetegedések során nemcsak fájdalomcsillapító és
Fürstál, Barbara
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Administração de canabinóides no sistema nervoso central facilita a extinção de memórias aversivas em ratos [PDF]
, 2008 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia.Recentemente, estudos têm demonstrado a capacidade do sistema endocanabinóide (eCB) em modular estados emocionais e ...
Bitencourt, Rafael Mariano de
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Silencing effect of shRNA-CB1 in HSCs.
, 2020 mRNA expression of CB1 in hepatic stellate cells transfected with plasmid that express three different sequences for a shRNA-CB1. pshCB1-A and pshCB1-B showed a significant percentage of CB1 mRNA inhibition compared to Irrelevant shRNA ...
Juan Armendáriz-Borunda (3589811) +9 more
core +1 more source
British Journal of Pharmacology, EarlyView.The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley +1 more source
British Journal of Pharmacology, EarlyView.Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley +1 more source
EPPO Bulletin, EarlyView.Abstract The ascomycetous fungus Cryphonectria carpinicola is typically found in its asexual form on the European hornbeam, and its sexual state has only recently been discovered in deadwood of different Carpinus species in Japan. Recently, this fungus has been added to the EPPO Alert List due to its increasing incidence in the EPPO region and a ...
Carolina Cornejo +2 more
wiley +1 more source
Participação dos receptores canabinóides cerebrais na tolerância rápida e aguda do álcool [PDF]
, 2006 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia.Evidências sugerem que o sistema de neurotransmissão endocanabinóide modula o consumo de álcool.
Carvalho, José Inácio Lemos Monteiro
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The FEBS Journal, EarlyView.Circadian disruption via constant light induces sex‐specific remodeling of the microbiome, lipid mediators, and immune responses. Females exhibit broader gut microbiota alterations, reduced jejunal oxylipins, increased hypothalamic N‐acylethanolamines, and a more inflammatory cytokine profile. Muscle responses are sex‐ and fiber type‐dependent: females
Pejman A. Pashaki +7 more
wiley +1 more source