Results 91 to 100 of about 40,137 (231)

CB1 RECEPTOR

, 2021
CBD analogues with CB1 ...
Neyder Contreras-Puentes (6900158)
core   +1 more source

Targeting mechanosensitive cannabinoid receptor 1 with isoflavone prodrugs attenuates atherosclerotic endothelial dysfunction

Journal of Biomedical Science
Background Despite therapeutic advances, atherosclerosis remains a major global health challenge. Most current treatments target systemic risk factors rather than the diseased vascular wall.
Dai-Jung Chung, Shao-Peng Chen, Wei-Hsuan Liu, Chia-Yu Liu, Nan-Wei Su, Chen Hsu, Hsin-Ya Tsai, Kai-Chien Yang, Cho-Kai Wu, Sheng-Wei Lin, Jiun‑Jie Shie, Ming-Tao Zhao, Tzu-Tang Wei   +12 more
doaj   +1 more source

Metabolic Profiling of CB1 Neutral Antagonists [PDF]

, 2017
PIMSR is among the first neutral antagonists for the CB1R and was demonstrated pharmacologically to bind to the CB1R, yet not alter calcium flux. It was further shown computationally to be able to stabilize both the active and inactive states of CB1R revealing the molecular interactions that mechanistically afford the property of neutral antagonism ...
Herbert H, Seltzman, Rangan, Maitra, Katharine, Bortoff, Jay, Henson, Patricia H, Reggio, Daniel, Wesley, Joseph, Tam   +6 more
openaire   +2 more sources

Intra‐Abdominal Hemorrhage Following Endoscopic Retrograde Cholangiopancreatography in a Patient with a Cascade Stomach: A Case Report

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Intra‐abdominal hemorrhage is an extremely rare complication of endoscopic retrograde cholangiopancreatography (ERCP). We report a case of intra‐abdominal bleeding that occurred after ERCP for choledocholithiasis with cholangitis in a patient with a cascade stomach.
Masashi Miura, Naoki Okano, Yamato Ohara, Ryo Ikegami, Wataru Ujita, Hiroki Nakagawa, Yusuke Kimura, Kensuke Takuma, Takahisa Matsuda, Yoshinori Igarashi   +9 more
wiley   +1 more source

Pharmacological activation of CB1 and D2 receptors in rats: predominant role of CB1 in the increase of alcohol relapse

, 2008
The classical dopamine D2 receptor has been widely studied in alcoholism. Recently, different studies have explored the role of the CB1 receptor in alcohol-related behavior. In alcohol addiction, relapse is one of the central features.
Brooks, R.D., López Moreno, José Antonio, Moreno-Sanz, G., Navarro, M., Alén Fariñas, Francisco, Isabel de Tena, A., López-Jimenez, A.   +6 more
core   +1 more source

Cb1 Enhanced Osteogenic Differentiation Of Bmscs By Rescue Mitochondrial Metabolism

International Dental Journal
Aim or purpose: CB1 is the main effector of endogenous cannabinoid system, and our previous study verified CB1 enhanced the osteo/dentinogenic differentiation of dental mesenchymal stem cells (MSCs), which might be a target for alveolar bone regeneration.
Wanhao Yan
doaj   +1 more source

β‐Caryophyllene Mitigates Thioacetamide‐Induced Liver Fibrosis Through CB2‐Mediated Suppression of Necroptosis: A Therapeutic Investigation

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
β‐Caryophyllene is a multifunctional sesquiterpene with significant therapeutic potential. Our findings demonstrate that β‐caryophyllene exerts broad hepatoprotective effects through the activation of cannabinoid type 2 (CB2) receptors. These effects include suppression of oxidative stress–induced injury, attenuation of inflammatory responses ...
Lujain Bader Eddin, Seenipandi Arunachalam, Loay Lubbad, Fayez T. Hammad, Ernest Adeghate, Sandeep Subramanya, Shreesh Ojha   +6 more
wiley   +1 more source

Cannabinoid type-1 receptors in CaMKII neurons drive impulsivity in pathological eating behavior

Molecular Metabolism
Objectives: Overconsumption of palatable food and energy accumulation are evolutionary mechanisms of survival when food is scarce. These innate mechanisms becom detrimental in obesogenic environment promoting obesity and related comorbidities, including ...
Elena Martin-Garcia, Laura Domingo-Rodriguez, Beat Lutz, Rafael Maldonado, Inigo Ruiz de Azua   +4 more
doaj   +1 more source

Exploring the Ligand Efficacy of Cannabinoid Receptor 1 (CB1) using Molecular Dynamics Simulations

Scientific Reports, 2018
Cannabinoid receptor 1 (CB1) is a promising therapeutic target for a variety of disorders. Distinct efficacy profiles showed different therapeutic effects on CB1 dependent on three classes of ligands: agonists, antagonists, and inverse agonists.
Sang Won Jung, Art E. Cho, Wookyung Yu
doaj   +1 more source

Energy Transitions in Nigeria: The Evolution of Energy Infrastructure Provision (1800–2015)

Energies, 2016
The provision of energy infrastructure is essential for economic growth, social cohesion, and environmental sustainability. Understanding the multiple functions and services it provides us requires firstly a deeper understanding of the factors that ...
Norbert Edomah, Chris Foulds, Aled Jones
doaj   +1 more source