Results 11 to 20 of about 562,936 (248)
Oximes short-acting CB1 receptor agonists.
Bioorganic & Medicinal Chemistry, 2018 New oximes short-acting CB1 agonists were explored by the introduction of an internal oxime and polar groups at the C3 alkyl tail of Δ8-THC. The scope of the research was to drastically alter two important physicochemical properties hydrophobicity (log P)
M. Malamas +8 more
semanticscholar +3 more sources
Synthesis and activity of 4,5-diarylimidazoles as human CB1 receptor inverse agonists
Bioorganic and Medicinal Chemistry Letters, 2005 Structure-activity relationship studies directed toward the optimization of 4,5-diarylimidazole-2-carboxamide analogs as human CB1 receptor inverse agonists resulted in the discovery of the two amide derivatives 24a and b (hCB1 IC50 = 6.1 and 4.0 nM) which also demonstrated efficacy in overnight feeding studies in the rat for reduction in both food ...
Christopher Plummer +2 more
exaly +4 more sources
Analysis of Tolerance and Behavioral/Physical Dependence during Chronic CB1 Agonist Treatment: Effects of CB1 Agonists, Antagonists, and Noncannabinoid Drugs [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2013 Behavioral studies of chronic CB(1) receptor activation may provide a pharmacological approach to understanding efficacy-related differences among CB(1) ligands as well as mechanistic commonalities between cannabinoid and noncannabinoid drugs. In the present studies, the effects of CB(1) agonists [(6aR,10aR)-3-(1-adamantyl)-6,6,9-trimethyl-6a,7,10,10a ...
R. Desai +5 more
semanticscholar +3 more sources
Heteromerización de receptores de adenosina A2A, dopamina D2 y cannabinoides CB1. Implicaciones farmacológicas y funcionales. [PDF]
, 2007 [spa] La visión de los receptores acoplados a proteína G ha evolucionado en los últimos años. Clásicamente se consideraban unidades individuales capaces de producir una señal intracelular; actualmente, está aceptado que estas proteínas de membrana pueden
Carriba Domínguez, Paulina
core +6 more sources
Two Janus Cannabinoids That Are Both CB2 Agonists and CB1 Antagonists [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2017 The cannabinoid signaling system includes two G protein-coupled receptors, CB1 and CB2 These receptors are widely distributed throughout the body and have each been implicated in many physiologically important processes. Although the cannabinoid signaling system has therapeutic potential, the development of receptor-selective ligands remains a ...
Amey Dhopeshwarkar +4 more
semanticscholar +3 more sources
Cells, 2023 Cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2) are components in the endocannabinoid system that play significant roles in regulating immune responses. There are many agonists for the cannabinoid receptors; however, their effects on T cell
Nuchjira Takheaw +4 more
doaj +1 more source
Saudi Pharmaceutical Journal, 2023 Chemotherapy-induced peripheral neuropathy (CIPN) is one of chemotherapies’ most often documented side effects. Patients with CIPN experience spontaneous burning, numbness, tingling, and neuropathic pain in their feet and hands.
Amina M. Bagher +3 more
doaj +1 more source
Cannabinoids for the control of experimental multiple sclerosis [PDF]
, 2010 PhDThere have been numerous studies reporting that cannabinoids, both exogenous and endogenous, have a potential beneficial function during incidences of neurological damage.
Pryce, Gareth
core +4 more sources
Molecules, 2022 Selective modulation of peripheral cannabinoid receptors (CBRs) has potential therapeutic applications in medical conditions, including obesity, diabetes, liver diseases, GI disorders and pain.
George Amato +6 more
doaj +1 more source