Results 201 to 210 of about 22,655 (236)

CB1 Cannabinoid Receptor Ligands

Mini-Reviews in Medicinal Chemistry, 2005
The CB1 receptor is expressed in the central nervous system and numerous other tissues including heart, lung and uterus and has been recognized as an important therapeutic target for pain, appetite modulation, glaucoma, multiple sclerosis and other indications.
Ganesh A, Thakur, Spyros P, Nikas, Alexandros, Makriyannis   +2 more
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Allosteric Modulation of the Cannabinoid CB1 Receptor

Molecular Pharmacology, 2005
We investigated the pharmacology of three novel compounds, Org 27569 (5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide), Org 27759 (3-ethyl-5-fluoro-1H-indole-2-carboxylic acid [2-94-dimethylamino-phenyl)-ethyl]-amide), and Org 29647 (5-chloro-3-ethyl-1H-indole-2-carboxylic acid (1-benzyl-pyrrolidin-3-yl)-amide, 2 ...
Martin R, Price, Gemma L, Baillie, Adèle, Thomas, Lesley A, Stevenson, Morag, Easson, Richard, Goodwin, Adèle, McLean, Lorraine, McIntosh, Gillian, Goodwin, Glenn, Walker, Paul, Westwood, Julia, Marrs, Fiona, Thomson, Phillip, Cowley, Arthur, Christopoulos, Roger G, Pertwee, Ruth A, Ross   +16 more
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Cannabinoid Receptor 1 (CB1)

2021
CB1 receptors mediate most central nervous system effects ascribed to the phytocannabinoid Δ-9-tetrahydrocannabinol (THC). CB1 receptors are guanine nucleotide-binding regulatory protein-coupled receptors that primarily activate Gi/o proteins, resulting in the inhibition of adenylyl cyclase.
Glenn R. Rech, Samer N. Narouze
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Pharmacology of cannabinoid CB1 and CB2 receptors

Pharmacology & Therapeutics, 1997
There are at least two types of cannabinoid receptors, CB1 and CB2, both coupled to G-proteins. CB1 receptors are present in the central nervous system and CB1 and CB2 receptors in certain peripheral tissues. The existence of endogenous cannabinoid receptor agonists has also been demonstrated.
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CB1 cannabinoid receptor-mediated aggressive behavior

Neuropharmacology, 2013
This study examined the role of cannabinoid CB1 receptors (CB1r) in aggressive behavior. Social encounters took place in grouped and isolated mice lacking CB1r (CB1KO) and in wild-type (WT) littermates. Cognitive impulsivity was evaluated in the delayed reinforcement task (DRT).
Rodríguez-Arias, Marta, Navarrete, Francisco, Daza-Losada, Manuel, Navarro, Daniela, Aguilar, María A., Berbel, Pere, Miñarro, José, Manzanares, Jorge   +7 more
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Involvement of CB1 cannabinoid receptors in emotional behaviour

Psychopharmacology, 2002
Endogenous and exogenous cannabinoids acting through the CB1 cannabinoid receptors are implicated in the control of a variety of behavioural and neuroendocrine functions, including emotional responses, and learning and memory processes. Recently, knockout mice deficient in the CB1 cannabinoid receptor have been generated, and these animals result in an
Martin, Miguel, Ledent, Catherine, Parmentier, Marc, Maldonado, Rafael, Valverde, Olga   +4 more
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CB1 Cannabinoid Receptor-Mediated Cell Migration

The Journal of Pharmacology and Experimental Therapeutics, 2000
Recent studies have suggested that cell migratory responses are often mediated by G(i) protein-coupled receptors. Because it is known that CB1 cannabinoid receptors are coupled to pertussis toxin-sensitive G proteins, we proposed that CB1 may mediate cell migration.
Z H, Song, M, Zhong
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Pentacycle derivatives as cannabinoid CB1 receptor ligands

Bioorganic & Medicinal Chemistry Letters, 2009
Cannabinoid CB-1 receptors have been the focus of extensive studies since the first clinical results of rimonabant (SR141716) for the treatment of obesity and obesity-related metabolic disorders were reported in 2001. To further evaluate the properties of CB receptors, we have designed and efficiently prepared a series of pentacycle derivatives.
Suk Ho, Lee, Hee Jeong, Seo, Min Ju, Kim, Suk Youn, Kang, Sung-Han, Lee, Kwangwoo, Ahn, Minwoo, Lee, Ho-Kyun, Han, Jeongmin, Kim, Jinhwa, Lee   +9 more
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Substituted pyrimidines as cannabinoid CB1 receptor ligands

Bioorganic & Medicinal Chemistry Letters, 2009
Cannabinoid CB1 receptors have been the avenue of extensive studies since the first clinical results of rimonabant (SR141716) for the treatment of obesity and obesity-related metabolic disorders were reported in 2001. To further evaluate the properties of CB receptors, we have designed and efficiently prepared a series of substituted pyrimidines based ...
Min Ju, Kim, Jong Yup, Kim, Hee Jeong, Seo, Junwon, Lee, Sung-Han, Lee, Mi-Soon, Kim, Jahyo, Kang, Jeongmin, Kim, Jinhwa, Lee   +8 more
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CB1 cannabinoid receptor induction in experimental stroke

Annals of Neurology, 2000
Cannabinoids protect cortical neurons from ischemic injury by interacting with CB1 receptors. Because a variety of neuroprotective genes are induced in cerebral ischemia, we examined the effect of experimental stroke, produced by 20 minutes of middle cerebral artery occlusion in rats, on CB1 receptor expression.
K L, Jin, X O, Mao, P C, Goldsmith, D A, Greenberg   +3 more
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