Results 131 to 140 of about 25,158 (238)

Design and synthesis of Heterocyclic Compounds as CB2 Selective Agoists

, 2008
Cannabinoids are present in Indian hemp, Cannabis sativa L., and have been used since antiquity as medicinal agents(1). Interest in cannabinoid pharmacology has rapidly increased since the discovery of the endocannabinoid system (ECS), which includes ...
BENETTI, VERONICA
core  

Expression of cannabinoid CB1 receptors by vagal afferent neurons: Kinetics and role in influencing neurochemical phenotype

, 2010
The intestinal hormone cholecystokinin (CCK) inhibits food intake via stimulation of vagal afferent neurons (VAN). Recent studies suggest that CCK also regulates the expression of some G protein-coupled receptors and neuropeptide transmitters in these ...
Varro, Andrea, Burdyga, Galina, Dockray, Graham J., Dimaline, Rod, Thompson, David G.   +4 more
core   +1 more source

Modulation of the endocannabinoid system reduces inflammatory signalling in canine mammary carcinoma cells

Veterinary Record Open, Volume 13, Issue 1, June 2026.
Abstract Background Canine mammary carcinoma (CMC) is characterised by a chronic inflammatory microenvironment resembling human breast cancer; however, the upstream regulatory mechanisms driving this phenotype remain unclear. The endocannabinoid system (ECS) has emerged as a potential modulator of inflammation and tumour biology.
Gianluca Antonio Franco, Ylenia Marino, Claudia Rifici, Roberta Fusco, Davide di Paola, Salvatore Cuzzocrea, Giuseppe Catone, Cecilia Vullo, Enrico Gugliandolo   +8 more
wiley   +1 more source

Hippocampal subfield differences in people with and without recreational ketamine use: Insights from multi‐modal neuroimaging

Addiction, Volume 121, Issue 6, Page 1541-1556, June 2026.
Abstract Background and aims Recreational ketamine use has increased globally and is associated with psychiatric and cognitive concerns. The hippocampus in preclinical models shows damage and working‐memory disruption with repeated dosing. However, whether specific hippocampal subregions may differ in people with chronic ketamine use remains unclear ...
Yi‐Hsuan Liu, Chia‐Chun Hung, Marc N. Potenza, Kun‐Hsien Chou, Pei‐Lin Lee, Chu‐Chung Huang, Chiang‐Shan R. Li, Tony Szu‐Hsien Lee, Ching‐Po Lin   +8 more
wiley   +1 more source

Somatic and terminal CB1 receptors are differentially coupled to voltage-gated sodium channels in neocortical neurons. [PDF]

Cell Rep, 2023
Steiger LJ, Tsintsadze T, Mattheisen GB, Smith SM.   +3 more
europepmc   +1 more source

Identification and qualification of a new family of peptide endocannabinoids (Pepcans) showing negative allosteric modulation at CB1 receptors

, 2012
The alpha-hemoglobin-derived dodecapeptide RVD-hemopressin (RVDPVNFKLLSH) has been proposed to be an endogenous agonist for the cannabinoid receptor type-1 (CB1).
Eisen, D., Gertsch, J., Chicca, Andrea, Lerner, R., Poetz, O., Tamborrini, Marco, Bauer, Mark, Eisen, David, Pluschke, G., Lerner, Raissa, Gertsch, Jürg, Poetz, Oliver, Lutz, Beat, Chicca, A., Bauer, M., Tamborrini, M., Pluschke, Gerd, Lutz, B.   +17 more
core   +1 more source

Adolescent cannabis use and psychological distress from 2013 to 2023: A population‐based study in Ontario, Canada

Addiction, Volume 121, Issue 6, Page 1495-1507, June 2026.
Abstract Background and aims Epidemiologic research suggests that adolescent cannabis use is associated with psychological distress (i.e. depression and anxiety symptoms); however, most studies have relied on 20th‐century data, when cannabis was significantly less potent than today.
André J. McDonald, Amanda Doggett, Susan J. Bondy, Ian Colman, Steven Cook, Hayley A. Hamilton, Paul Kurdyak, Scott T. Leatherdale, Daniel T. Myran, Jürgen Rehm, Christine M. Wickens, James MacKillop, Jillian Halladay   +12 more
wiley   +1 more source

A Critical Evaluation of Terpenoid Signaling at Cannabinoid CB1 Receptors in a Neuronal Model. [PDF]

Molecules, 2022
Dvorakova M, Wilson S, Corey W, Billingsley J, Zimmowitch A, Tracey J, Straiker A, Mackie K.   +7 more
europepmc   +1 more source

Synthesis of novel allosteric modulators for the cannabinoid CB1 receptors

, 2014
The CB1 cannabinoid receptor is a widely distributed G-protein coupled receptor in human central and peripheral system. It is the most abundant GPCR in the brain.
Damaraju, Venkata Surya Aparna
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Cannabidiol and cannabigerol ameliorate steatotic liver disease via phosphocreatine buffering and lysosomal restoration

British Journal of Pharmacology, Volume 183, Issue 12, Page 3173-3194, June 2026.
Cannabidiol (CBD) and cannabigerol (CBG) alleviate hepatic steatosis in obese mice by shifting energy buffering towards phosphocreatine and enhancing lysosomal lipid degradation and trafficking. These effects are associated with increased creatine kinase activity and lysobisphosphatidic acid (LBPA) levels, highlighting a previously unrecognised ...
Radka Kočvarová, Shahar Azar, Bella Agranovich, Ifat Abramovich, Saveliy Kirillov, Alina Nemirovski, Saja Baraghithy, Inbar Plaschkes, Emmanuelle Merquiol, Alexander Rouvinski, Galia Blum, Liad Hinden, Joseph Tam   +12 more
wiley   +1 more source